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Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology


ISSNİ0172ñ780X Copyrightİ©İ1998 NeuroendocrinologyİLetters

NEL Vol. 18 No. 1
Original Article

1998; 18:15-20
pii: NEL180197A03


Suppression of N-nitroso-N-methylurea-induced second generation rat mammary tumors with combined melatonin-tamoxifen therapy

by Lalita Kothari, Ami Kothan , Anita Borges, Indranil Mitra, Sharayu Kabre

Cell Biology Division , Cancer Research Institute. Department of Pathology , Tumor Marker Laboratory , Tata Memorial Hospital, Tata Memorial Centre, Parel, Bombay 400012

Received: April 27, 1996


Sprague-Dawley rats were injected with N-nitroso-N-methylurea (NMU) (50mg/kg b.wt.) and the primary tumor which developed within three months were excised. These tumors were found to be ER +ve (50±4.3 fmol/mg protein). Animals were regrouped following excision and melatonin (Mel) and/or tamoxifen (Tarn) treatment was initiated immediately. There was uniform and significant delay in secondary tumor appearance in all the treated groups as compared to the untreated NMU-administered animals. The most effective suppression was observed in animals treated with combined therapy and histopathologically, these tumors were benign. The combination of melatonin and tamoxifen in women having ER+ve tumors appears to be a useful therapeutic approach.

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