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Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology


ISSNİ0172ñ780X Copyrightİ©İ1998 NeuroendocrinologyİLetters

NEL Vol. 18 No. 1
Original Article

1998; 18:21-26
pii: NEL180197A04


Human prolactinomas in cell culture: structure-function correlation and indication of early relapse

by Chih-Jen Wang* and Shen-Long Howng

Division of Neurosurgery, Department of Surgery, Kaohsiung Medical College, 100, Shih-Chuan 1st Road, Kaohsiung, Taiwan

Received: January 5, 1997


Cell cultures of 7 micro-and 16 macroprolactinomas obtained from twenty-three patients (10 males and 13 females) by transsphenoidal adenomectomies were found to be capable of secreting hormones in vitro. Prolactin levels in the culture media were measured during the culture periods and showed that the high PRL levels in culture media may indicate early relapse Morphological features of both micro-and macroprolactinomas in vitro resembled those of the original tumors. Most macroprolactinomas harbored densely-granulated cells, while microprolactinomas sparsely-granulated cells. The cell culture techniques combined with morphological studies of prolactinomas allow further investigation of structure-function correlation in human prolactinomas.

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