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Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology


ISSNİ0172ñ780X Copyrightİ©İ1997 NeuroendocrinologyİLetters

NEL Vol. 18 No. 2/3
Original Article

1998; 18:135-140
pii: NEL182397A05


Involvement of Nitric Oxide in the Ameliorative Effect of Vasoactive Intestinal Peptide on Impaired Performance Induced in Rats by Scopolamine in Radial-Arm Maze
by Yoshimasa Yamaguchi, Masaya Higashi, Hidestu Kobayashi


A single intrapentoneal (IP) injection of vasoactive intestinal peptide (VIP) (65 (µg/kg) had ameliorative effects on impaired performance induced in rats by scopolamine in a radial-arm maze. This effect of VIP was nullified when NG-nitro-L-arginine methyl ester (L-NAME), a specific inhibitor of nitric oxide (NO)-synthase, was given singly at doses of 50 or 100 mg/kg in combination with VIP These results suggest that the ameliorative action of VIP may be partly due to an increase of cerebral blood flow mediated by NO, which is an endothelium-derived relaxing factor in blood vessels.

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