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Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology


ISSNİ0172ñ780X Copyrightİ©İ1997 NeuroendocrinologyİLetters

NEL Vol. 18 No. 4
Original Article

1998; 18:190-196
pii: NEL182397A01


Evidence for Prolactin Releasing Activity of Neuropeptide FF in Rats
by Antti A.Aamisalo, Raimo K.Tuominen, Maija Nieminen, Petri Vainio and Pertti Panula

Received: June 10, 1997;
Accepted: August 15, 1997


Neuropeptide FF (NPFF) is found in high concentrations in the pituitary and spinal cord of rat. We have measured the effect of NPFF on the release of thyroid-stimulating hormone (TSH), growth hormone (GH) and prolactin (PRL). NPFF released PRL in vivo and in vitro in male rats. NPFF was more effective than thyrotropin-releasing hormone (TRH) in vitro in AP cell cultures of male rats. NPFF had no effect on the release of GH or TSH from AP cells in vitro. One of the functions of hypothalamic NPFF may be regulation of the anterior lobe and release of prolactin from the lactotropes. The lactotropes may contain functional receptors for NPFF. Our results also support the importance of multiple factors in coordinated regulation of PRL release.

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