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Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology


ISSNİ0172ñ780X Copyrightİ©İ1997 NeuroendocrinologyİLetters

NEL Vol. 18 No. 4
Original Article

1998; 18:215-220
pii: NEL182397A04


Estrogen-Brain Relationship During Development and Aging: Effects on Glial Cells
by R. Kapur and P S. Timiras

Received: November 14, 1997
Accepted: November 24, 1997


17-b-estradiol stimulates glial cell growth beginning at 5 days in culture, the highest proliferation occuring with the highest hormone concentration. Activity of glutamine synthetase and cyclic nucleotide phosphohydrolase, markers for astrocytes and oligodendrocytes, respectively, is also increased, the highest concentration inducing the greatest activity. These changes may represent one of the mechanisms of the neuroprotective actions ofestrogens.

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