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NeuroendocrinologyİLetters
ISSNİ0172ñ780X Copyrightİ©İ1998 NeuroendocrinologyİLetters

NEL VOL. 19 No. 1
ORIGINAL ARTICLE

1998; 19:21-25


Sympathetic Regulation of Immune Response in Cadmium Exposed Mice
by Shyam Bala Lall and Gargi Dan


Abstract:

Immunomodulatory role of sympathetic nervous system (SNS) on the humoral and cell mediated immunity (CMI) in Cadmium (Cd) exposed mice was investigated. The effect of treatment with Cd (300 ppm), Cd+phenoxybenzamine, Cd+propranolol and Cd+normadate on the immune response was observed after 35 days of exposure. The results of each group were compared with that of their respective controls. The Cd induced immunosuppressive effect on humoral and CMI was not affected by phenoxybenzamine. However, treatment with propranolol and normadate significantly (p < 0.05) increased the humoral and cell mediated immunity which was markedly suppressed when these drugs were co-administered with Cd. The results indicate that Cd induced immunosuppression may involve the beta adrenergic receptors.

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