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NeuroendocrinologyİLetters
ISSNİ0172ñ780X Copyrightİ©İ1998 NeuroendocrinologyİLetters

NEL VOL. 19 No. 1
ORIGINAL ARTICLE

1998; 19:27-32

 

Responsiveness of the Reproductive System to Pineal Hormones and to Serotonergic Drugs in the Developing and in the Aging Rat
by Csilla Ruzsas and Kazuhiko Shirama


Abstract:

In the present study, age-dependent action of pineal hormones and serotonergic drugs was demonstrated in 2 types of constant estrous-anovulatory (CEA) syndrome, in 2 critical intervals of sexual development:

  • 1. CEA syndrome induced in the perinatal age by androgen sterilization (NA-CEA state),
  • 2. spontaneously developed CEA syndrome present in aging rats during the period of reproductive senescence (AG-CEA state).

Interventions affecting pineal gland or brain serotonergic neurons were weakly influential on NA-CEA state. In AG-CEA rats, however, reappearance of cyclicity was induced by drugs increasing serotonergic tone, while daily melatonin treatment was less effective in this respect. - On the other hand, the results also suggest that modification of peripheral sexual steroid blood levels might also contribute to the reproductive dysfunction in the observed 2 types of CEA syndromes.

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