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Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology

 

NeuroendocrinologyİLetters incl. Psychoneuroimmunology & Chronobiology,
ISSNİ0172ñ780X Copyrightİ©İ1998, 1999, 2000, 2001 NeuroendocrinologyİLetters

NEL VOL. 19 No. 2
INVITED NEL REVIEW

1998; 19:71-78

 

Antiproliferative Effects of Melatonin and CGP 52608 on the Murine Colon 38 Adenocarcinoma. In Vitro and In Vivo
by
Michal Karasek, Katarzyna Winczyk, Jolanta Kunert-Radek, Irmgard Wiesenberg & Marek Pawlikowski

Abstract:

The pineal gland hormone melatonin and structurally novel class of thiazolidinediones represented by the lead structure CGP 52608 have been shown to specifically activate the receptor RZR/RORa, a member of the nuclear receptor superfamily of ligand-inducible transcription factors. The effects of melatonin and CGP 52608 on the proliferation of the murine Colon 38 adenocarcinoma cells were studied in vitro and in vivo. Melatonin and CGP 52608, inhibited in vitro [3H]-thymidine incorporation into DNA in concentrations of 10-5, 10-7 and 10-9 M, with the most effective being 10-7 M. Tumor cell proliferation in vivo as measured by bromodeoxyuridine incorporation was also significantly inhibited by daily subcutaneous injections of melatonin or CGP 52608 (10µg and 100 µg/animal). These results do not finally prove, but support the hypothesis that nuclear signaling via RZR/RORa receptors may be involved, at least in part, in mediating the oncostatic effects of the pineal gland hormone melatonin.

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