Neuroendocrinology Letters, Home
Neuroendocrinology Letters Vol. 19 Contents
Contact us
Subscription info
Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology


NeuroendocrinologyİLetters incl. Psychoneuroimmunology & Chronobiology,
ISSNİ0172ñ780X Copyrightİ©İ1998, 1999, 2000, 2001 NeuroendocrinologyİLetters

NEL VOL. 19 No. 2

1998; 19:71-78


Antiproliferative Effects of Melatonin and CGP 52608 on the Murine Colon 38 Adenocarcinoma. In Vitro and In Vivo
Michal Karasek, Katarzyna Winczyk, Jolanta Kunert-Radek, Irmgard Wiesenberg & Marek Pawlikowski


The pineal gland hormone melatonin and structurally novel class of thiazolidinediones represented by the lead structure CGP 52608 have been shown to specifically activate the receptor RZR/RORa, a member of the nuclear receptor superfamily of ligand-inducible transcription factors. The effects of melatonin and CGP 52608 on the proliferation of the murine Colon 38 adenocarcinoma cells were studied in vitro and in vivo. Melatonin and CGP 52608, inhibited in vitro [3H]-thymidine incorporation into DNA in concentrations of 10-5, 10-7 and 10-9 M, with the most effective being 10-7 M. Tumor cell proliferation in vivo as measured by bromodeoxyuridine incorporation was also significantly inhibited by daily subcutaneous injections of melatonin or CGP 52608 (10µg and 100 µg/animal). These results do not finally prove, but support the hypothesis that nuclear signaling via RZR/RORa receptors may be involved, at least in part, in mediating the oncostatic effects of the pineal gland hormone melatonin.

Copyright © Neuroendocrinology Letters 1998, 1999, 2000, 2001
All rights reserved. No part may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or ortherwise, without prior written permission from the Editor-in-Chief