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Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology


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NeuroendocrinologyİLetters incl. Psychoneuroimmunology & Chronobiology,
ISSNİ0172ñ780X Copyrightİ©İ1998, 1999, 2000, 2001 NeuroendocrinologyİLetters

NEL VOL. 19 No. 3
ORIGINAL ARTICLE

1998; 19:159-163

 

Effect of Naloxone on Immunoreactive Parathyroid Hormone in Cerebrospinal Fluid and Plasma in Sheep
by Georg Bühler, Svetla Balabanova & Julian Rosenthal

 

Abstract:

In the present study the effects of naloxone on parathyroid hormone (PTH) as well as total calcium (Ca) and magnesium (Mg) concentrations in plasma and cerebrospinal fluid (CSF) of sheep were investigated. Blood and CSF samples had been obtained simultaneously at intervals following naloxone administration. CSF and plasma PTH were determined by radioimmunoassay (RIA). The results show that naloxone provoked a decrease of PTH concentrations in CSF, whereas plasma PTH levels remained approximately unchanged. No changes of Ca and Mg in plasma and CSF were observed. These results suggest that PTH participates, at least partly, in the effect of naloxone.

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