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Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology


NeuroendocrinologyİLetters incl. Psychoneuroimmunology & Chronobiology,
ISSNİ0172ñ780X Copyrightİ©İ1998, 1999, 2000, 2001 NeuroendocrinologyİLetters

NEL VOL. 19 No. 4

1998; 19:181-189


Effectiveness of Ubiquitin Therapy of Sensorineural Hearing Loss in Children
by Elzbieta Reron, Gabriel Turowski & Eugeniusz Olszewski


Ubiquitin biotherapy has been administered of 20 patients aged from 5 to 14 with bilateral progressive sensorineural hearing loss (SNHL) of unknown etiology lasting from several months to three years. An extract from calf thymuses-Thymus Factor (TFX) was applied intramuscularly in a daily dose 10 mg of active substance. Initially TFX was given four times a week, then three times a week and finally twice a week within 12 to 18 months. In a group of 14 patients with bilateral progressive SNHL all children have shown in audiometric examinations an improvement of about 20 to 75 dBnHL within the range of frequencies relevant for understanding speech and moreover, increased speech discrimination. The obtained improvement in hearing enabled four patients from the group to give up hearing aids that they had been using for one to three years. In six other patients from SNHL group the obtained hearing improvement of about 20 to 25 dBnHL within the range of intensity from 70 to 90 dB has not essentially affected improvement in speech understanding, it has however, enabled to use hearing aids with significantly less amplification at the input of the hearing aid. Encouraging results of the effective treatment of bilateral and progressive SNHL with unknown etiology substantiate the continuation of ubiquitin biotherapy in these cases. In the same time one may suggest it may become a new strategy in the treatment.

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