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Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology


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NeuroendocrinologyİLetters incl. Psychoneuroimmunology & Chronobiology,
ISSNİ0172ñ780X Copyrightİ©İ1998, 1999, 2000, 2001 NeuroendocrinologyİLetters

NEL VOL. 19 No. 4
ORIGINAL ARTICLE

1998; 19:207-214

 

Ultrastructural Analysis of Rat’s Hypothalamo-Neurohypophysial System in a New Experimental Model of Clinical Death
by Barbara Gajkowska & Andrzej Kapuscinski


Abstract:

The purpose of this study was to analyze ultrastructural changes in neurosecretory system in rats with permanent bilateral common carotid artery occlusion that survived two months after cardiac arrest. In this model severe ultrastructural changes in the supraoptic and paraventricular nuclei took place. Observed damage of neurosecretory neurons and their axons, activation of microglial and inflammatory cells and dysfunction of blood-brain barrier suggest reduction in the secretory process in hypothalamo-neurohypophysial system. Our model allows to investigate the mechanism of ischemic injury.

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