This issue of the Neuroendocrinology Letters will be the last for this year and I take this opportunity to sincerely thank all of the authors and peer-reviewers who have contributed to the six published issues.
As we near the end of this century, I feel more strongly than ever that the transdisciplinary nature of this Journal has proven to be the essence in the neurosciences. These determinations were posed in Aim & Scope as well as in my previous Editorial (Vol. 20, Nos. 1/2) and in the Philosophy behind Science (Psychoimmuno-neuroendocrinology: An Integrative Approach to Modern Philosophy in Medicine and Psychology, Vol. 20, Nos. 3/4). They were also addressed in the Guest Editorial by Ario Conti and Georges J.M. Maestroni which appears in the current issue.
We consider the broad topic of Neuroimmunomodulation as part of the integrated psychoimmuno-neuroendocrinological system and as a bridge between the immune system, neuroendocrinology and the rest of the central nervous system. This in turn opens the gateway to a comprehensive approach to the neurosciences as a whole.
Moreover, the basic concept of this Journal, the indivisibility between science and art and the continuity in the intellectual and creative nature behind every scientific work, acts as the bond between the two.
The vision of the sciences for the new millennium lies in this transdisciplinary approach and the nature of both theoretical and clinical disciplines and sci-ences which meet and undergo a process of "cross-fertilization." Hand in hand with that is the conviction of the indivisibility of the somatic and psychological processes as well as the inseparability of the developmental functions of the central nervous system.
The immunological and neuroendocrine processes are an indivisible continuum of human life from its very inception. To be instrumental in the realization of this vision, the Neuroendocrinology Letters is certainly the best channel to mediate cooperation between the different disciplines and sciences. These aspects were also expressed in the Review Articles, Original Papers and Guest Editorials published in the Neuroendocrinology Letters during this year such those by Franz Halberg, Michal Karasek, Manuchair Ebadi, Paolo Lissoni, Vera Stejskal, Ario Conti, Georges J.M. Maestroni and others.
From the Editorial Office of the Neuroendocrinology Letters, we wish all of you a prosperous, creative, healthy and innovative year 2000. I am confident that with your continued support, the Neuroendocrinology Letters will be heralded as one of the pioneering forums within the integrated neurosciences.