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Neuroendocrinology Letters Vol. 20 No. 6 Contents
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Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology, Research papers.
ISSN 0172–780X Copyright © 2000 Neuroendocrinology Letters

NEL Vol. 20 No. 6
Original Article
1999; 20:379–383

Interaction between central effects of ethanol and melatonin in mice

by Elzbieta
Czarnecka, Elzbieta Kubik-Bogucka & Jaroslaw S. Strzelec

melatonin, ethanol, CNS, interaction, mice

Effects of melatonin on acute toxicity of ethanol and ethanol-induced hypothermia, ethanol and thiopental sleeping time and ethanol-induced hypermotility were investigated in mice. The melatonin (1 and 5 mg/kg) was injected i.p. in single or repeated doses (7 days). The experiments were performed during the light phase of the light/dark cycle. It has been shown that a single dose of melatonin shortened duration of ethanol sleep and decreased ethanol-induced hyperactivity in mice. Melatonin given to mice for 7 days did not influence ethanol-induced effects. Melatonin prolonged thiopental hypnotic effect. The results of central interaction of ethanol and melatonin may be of antagonistic or synergistic nature.


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