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Neuroendocrinology Letters Vol. 21 No. 1 Contents
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Neuroendocrinology›Letters incl. Psychoneuroimmunology & Chronobiology, Review -Research Papers.
ISSN›0172Ů780X Copyright›©›2000 Neuroendocrinology›Letters

NEL Vol. 21 No. 1
Invited NEL Review

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2000; 21:17–23

Melatonin and aging. A brief survey
by Csilla Rôzs∑s1 & B»la Mess

Keywords:
aging, melatonin, ovarian cycle, anovulatory syndrome, serotonin, monoaminergic neurons, suprachiasmatic nuclei

Abstract:
The relationship between the pineal gland and aging has been assumed already nearly a century ago. Recently, melatonin was considered by some authors as a žwonder drug.Ó The present paper tries to summarize the relationship between melatonin and aging in three points.
1. Decline of melatonin production during aging.
2. The role of the pineal gland in the regulation of the ovarian cycle in aged females.
3. The antioxydant effect of melatonin and aging.

The age-related decline of pineal melatonin production is due to the degenerative changes of the neural structures (serotonergic and noradrenergic neuron systems) innervating the pineal gland and the suprachiasmatic nuclei rather than to the degeneration of the pineal tissue itself. The decreased melatonin production of the pineal gland preceds the destruction of ovarian cyclicity which can be partly counteracted by melatonin or by 5-hydroxytryptophane administration. The antioxydant effect of melatonin might explain its lifespan-prolonging effect, at least to a certain degree.

Neuroendocrinology Letters incl Psychoneuroendocrinology, Chronobiology:
A peer-reviewed transdisciplinary Journal covering neuroendocrinology, psyhoneuroimmunology and chronobiology. Publishing basic and clinical research papers, review articles and state-of the art from the basic research and clinical research. E-mail: info@nel.edu
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