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NeuroendocrinologyİLetters incl. Psychoneuroimmunology & Chronobiology,
Review -Research Papers.
ISSNİ0172ñ780X Copyrightİ©İ2000 NeuroendocrinologyİLetters

NEL Vol. 21 No. 1
Original Article

2000; 21:47–49

Effect of 24, 25-dihydroxycholecalciferol on the placental immunoreactive calcitonin
by Georg B¸hler, Svetla Balabanova & Julian Rosenthal

GH; GH-RH; estradiol; progesterone

OBJECTIVES: Calcitonin (CT) has a regulative function in calcium (Ca) transfer from mother to the fetus. There are indications that cholecalciferol can play a role in this process. With this background, the effect of 24, 25-dihydroxycholecalciferol (24, 25-DHC) on immunoreactive CT by human placenta at term was studied in vitro.

METHODS: Placental tissue samples were incubated in culture medium with normal total Ca (1.3 mM) concentrations during 6 hours at 37ƒC. 24, 25-DHC was added to the samples.

RESULTS: Addition of 24, 25-DHC in concentrations of 25, 75 and 150 pg/ml was followed by a significant decrease of CT levels in medium. The concentrations decreased from 100% (basis value after 2 hours) to 31%, 46% and 49% respectively.

CONCLUSION: Probably 24, 25-DHC has a modulating effect on the regulation of placental Ca transfer by CT.


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