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Neuroendocrinology Letters Vol. 21 No. 6 Contents
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Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology


Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology,
ISSN 0172–780X Copyright © 2000 Neuroendocrinology Letters

NEL VOL. 21 No. 6

2000; 21:437-439
pii: NEL21062000A002

Melatonin concentrations in patients with large goiter before and after surgery
by Michal Karasek, Aleksander Stankiewicz, Elzbieta Bandurska-Stankiewicz, Krystyna Zylinska, Marek Pawlikowski & Krzysztof Kuzdak

melatonin; goiter; thyroidectomy


OBJECTIVES. Surgical removal of a very large goiter may traumatize adjacent anatomical structures. The manipulations that involve superior cervical ganglia may alter melatonin secretion. To test this hypothesis we decided to study diurnal serum melatonin profiles in patients with a very large goiter before and after the surgery.

MATERIAL AND METHODS. The study was performed on 10 women (mean age–46.5±1.6 years; mean±SEM; range 39–54 years) with very large non-toxic nodular goiter (mean thyroid volume—125.8±25.9 cm3; mean±SEM; range 82.6–326.7 cm3). Diurnal serum melatonin profiles were estimated two days before the operation and 10 days after the surgery. Blood samples were collected at 08:00, 12:00, 16:00, 20:00, 22:00, 24:00, 02:00, 04:00, 06:00 and 08:00 h. Melatonin concentration was measured using RIA kit.

RESULTS. Nocturnal serum melatonin concentrations (at 24, 02, and 04 hours) were significantly higher after the surgery than before the operation.

CONCLUSIONS. Very large goiter may compress the superior cervical ganglia altering indirectly the melatonin synthesis. It cannot be excluded, however, that the presence of the large goiter in some other way affects melatonin secretion.


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