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Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology

 

NeuroendocrinologyİLetters incl. Psychoneuroimmunology & Chronobiology,
ISSNİ0172ñ780X Copyrightİ©İ2000 NeuroendocrinologyİLetters

NEL VOL. 22 No. 2
ORIGINAL ARTICLE

Full text pdf (258kb)

2001; 22:87-92
pii: NEL220201A02
PMID: 11335884


Focal ischemia in the cerebral cortex has an effect on the neurohypophysis
II. Angiogenesis in the neurohypophysis is a consequence of the focal ischemia in the cerebral cortex

by
Malgorzata Frontczak-Baniewicz & Barbara Gajkowska

Keywords:
capillary vessel, basement membrane, extracellular matrix, angiogenesis

Submitted: February 14, 2001
Accepted: March 16, 2001

Abstract:

OBJECTIVES: Focal ischemia in the cerebral cortex has an effect on neurohypophysis. The morphological changes of microvessels of neurohypophysis were evaluated in a model of the cerebral infarction initiated by a photochemical reaction in the cerebral cortex. After photochemically induced platelet aggregation, we observed the morphological features of angiogenesis.

METHOD: The model of photochemically-induced cerebral ischemia was used. Seven days after intravenous injection of rose bengal and irradiation from a halogen lamp source through an intact cranium, the sampled material from neurohypophysis is processed for transmission electron microscopy using standard procedures.

RESULTS: We observed morphological features of the new vessel formation: the alterations in the endothelium and extracellular matrix during separation of the endothelial cell from each other in a “mother” vessel, the migration of the endothelial cells in the extracellular matrix, the communication of the lumen of the new and the “mother” vessels.

CONCLUSION: We observed development of the angiogenic phenotype in the neurohypophysis after focal ischemia in the cerebral cortex. The endothelium, basement membrane and extracellular matrix undergo morphological alterations which lead to new blood vessel formation.

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