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Neuroendocrinology Letters Vol. 22 No. 1 Contents
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Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology


NeuroendocrinologyİLetters incl. Psychoneuroimmunology & Chronobiology,
ISSNİ0172ñ780X Copyrightİ©İ2000 NeuroendocrinologyİLetters

NEL VOL. 22 No. 2

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2001; 22:121-127
pii: NEL220101A06
PMID: 11335888

Assessment of the relationship between circadian variations of salivary melatonin levels and type I collagen metabolism in postmenopausal obese women
Zofia Ostrowska, Beata Kos-Kudla, Bogdan Marek, Elzbieta Swietochowska & Janusz GÛrski

melatonin, metabolism of type I collagen, postmenopausal obese women

Submitted: January 21, 2001
Accepted: February 06, 2001


BACKGROUND: Few experimental and clinical studies show that melatonin (MEL) can play a significant part to modulate circadian bone metabolism. On this basis it was suggested that MEL secretion which altered during 24-h in obese women could be of importance to regulate bony mass defect after menopause.

OBJECTIVE: The aim of the study was to prove if there were any connection between changes in 24-h profile of serum MEL levels and circadian metabolism of type I collagen in postmenopausal women with visceral obesity.

METHODS: The relationship of 24-h profile of salivary MEL and circadian metabolism of type I collagen (as assessed by measuring saliva concentrations of carboxyterminal propeptide of type I procollagen - PICP and cross-linked carboxyterminal telopeptide of type I collagen - ICTP) was investigated in 26 women with visceral obesity (33.5 < BMI < 42.1 kg/m2) and 18 healthy volunteers with correct body mass (21 < BMI < 24.5 kg/m2; 0.73 < WHR < 0.76). The specimens were collected at subjects’ home at 3 h intervals during a 24 h span. The age range of all subjects was 52–60 years.

RESULTS: In all the obese women studied a tendency to suppress circadian levels of tested biochemical markers of bone metabolism was observed (especially regarding ICTP); those alterations were accompanied by substantial increment in MEL concentrations during the day. Significant and negative correlation was found between values of acrophase MEL and PICP rhythms and both amplitude and acrophase of MEL and ICTP rhythms.

CONCLUSION: Our results confirm hypothesis that alterations in MEL concentrations might have a protective effect against postmenopausal loss of bone mass.

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