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Neuroendocrinology Letters Vol. 22 No. 3 Contents
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Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology

NeuroendocrinologyİLetters incl. Psychoneuroimmunology and Chronobiology, Editorial.
ISSNİ0172ñ780X Copyrightİ©İ2001 NeuroendocrinologyİLetters

NEL VOL. 22 No. 3
Original Article

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2001; 22:181-185
pii: NEL220301A02

Effect of melatonin administration on activities of some lysosomal enzymes in the mouse
by Bozena Witek, Ewa Ochwanowska, Adam Kolataj, Alina Slewa & Iwona Stanislawska

exogenous melatonin, lysosomal compartment, glycosidases, proteolytic enzymes, lysosomal acid lipase, mice, adaptation

Submitted: March 3, 2001
Accepted: May 8, 2001


OBJECTIVES: Changes in the activity of b-glucuronidase, N-acetyl-b-glucosaminidase, cathepsin D and L, alanine aminopeptidase and lysosomal acid lipase in lysosomal fractions of the liver and kidneys of mice, which were administered 20 mg/kg b.w. of exogenous melatonin (N-acetyl-5-methoxytryptamine) for 7 and 14 days were investigated.

METHODS: The slices of the liver and kidney were homogenized in 0. 1M phosphate buffer, pH 7.0. Homogenates were subjected to differentiated centrifuging and determination of studied enzymes.

RESULTS: Melatonin caused lowering of the activity of all the investigated lysosomal enzymes in the liver and kidney.

CONCLUSION: Administration of melatonin was caused the lowering of the activity of the investigated lysosomal enzymes in comparison with values in control groups.

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