Changes in the activity of b-glucuronidase,
D and L, alanine aminopeptidase and lysosomal acid lipase
in lysosomal fractions of the liver and kidneys of mice, which
were administered 20 mg/kg b.w. of exogenous melatonin (N-acetyl-5-methoxytryptamine)
for 7 and 14 days were investigated.
METHODS: The slices of the liver and kidney were homogenized
in 0. 1M phosphate buffer, pH 7.0. Homogenates were subjected
to differentiated centrifuging and determination of studied
RESULTS: Melatonin caused lowering of the activity of all
the investigated lysosomal enzymes in the liver and kidney.
CONCLUSION: Administration of melatonin was caused the lowering
of the activity of the investigated lysosomal enzymes in comparison
with values in control groups.