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Neuroendocrinology Letters Vol. 22 No. 3 Contents
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Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology

Neuroendocrinology›Letters incl. Psychoneuroimmunology and Chronobiology, Editorial.
ISSN›0172Ů780X Copyright›©›2001 Neuroendocrinology›Letters

NEL VOL. 22 No. 3
Invited Review Article

Full text pdf (169kb)

2001; 22:175-180
pii: NEL220301R02

A review on cancerpsychospiritual status interactions
by Paolo Lissoni, Pino Cangemi, Domenico Pirato, Maria Grazia Roselli, Franco Rovelli, Fernando Brivio, Fabio Malugani, Georges JM Maestroni, Ario Conti, Mosh» Laudon, Ola Malysheva & Luisa Giani

consciousness, immunomodulation, pineal gland, psychoanalysis, sexuality

Submitted: May 10, 2001
Accepted: May 25, 2001


With the advances in the knowledge of neuroimmunomodulation, a new era of investigations about the chemical basis of the state of mind has been initiated. Both emotions and states of spiritual consciousness may influence immune functions and cancer growth. Stress, anxiety and depressive states are associated with immunosuppression and enhanced frequency of tumors. On the other hand, the states of sexual pleasure and spiritual joy enhance the immune efficacy, by counteracting tumor onset and dissemination. The biochemistry of pleasure and immunostimulation is mainly mediated by pineal indoles and cannabinergic substances, whereas that of stress, anxiety and depression is associated with enhanced production of adrenal steroids, opioids and catecholamines. The sexual repression would allow a progressive immunosuppression through a profound damage in the biochemistry of pleasure. Therefore, a better definition of psychospiritual status-associated neuroimmunochemistry could allow us to improve the immune dysfunction by acting on the same neuroendocrine secretions which are involved in mediating the psychic influence on the immunity, including that against cancer.

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