Neuroendocrinology Letters, Home
Neuroendocrinology Letters Vol. 22 No. 4 Contents
Contact us
Subscription info
Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology

NeuroendocrinologyİLetters incl. Psychoneuroimmunology and Chronobiology, Editorial.
ISSNİ0172ñ780X Copyrightİ©İ2001 NeuroendocrinologyİLetters

NEL VOL. 22 No. 4
Clinical Report

Full text pdf (76kb)

2001; 22:248-250
pii: NEL220401C02
PMID: 11524631

High incidence of hyperandrogenism-related clinical signs in patients with multiple sclerosis
by Paolo Falaschi, Antonio Martocchia, Antonella Proietti, Rosaria DíUrso & Giovanni Antonini

MS, hyperandrogenism, premenstrual syndrome, sex hormones, oral contraceptives

Submitted: July 9, 2001
Accepted: July 17, 2001


A mild prevalence of multiple sclerosis (MS) is present in females (2:1). To elucidate the pathogenetic role of sex steroids on the disease, we studied 76 women affected by MS, compared to 50 healthy women (mean age ± SD, 34.9 ± 0.9 vs 33.4 ± 1.7 years). The menarche was at mean age of 12.3 ± 0.2 vs 12.4 ± 0.2. Interval between menses was 28.0 ± 0.3 vs 27.8 ± 0.3 days, with duration of menstrual flow of 5.0 ± 0.2 vs 5.0 ± 0.2 days. Oligo- or amenorrhea was present in 20% of patients and in 16% of controls. Oral contraceptives were assumed by 21% of patients and 34% of controls (n.s.). Premenstrual symptoms were found in 43% of patients and in 46% of controls (n.s.). The incidence of hyperandrogenism (greasy skin, acne and hirsutism), evaluated by a specific questionnaire, was higher and statistically significant in MS patients than in controls (28% vs 10%, p<0.05). Further studies, including a complete clinical and laboratory evaluation of gonadal function, are necessary in order to clarify whether hyperandrogenism may influence MS disease activity.


Copyright © Neuroendocrinology Letters 2001
All rights reserved. No part may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or ortherwise, without prior written permission from the Editor-in-Chief.