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Vol. 22 No. 5 Contents
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Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology

including Psychoneuroimmunology, Neuro
Reproductive Medicine, Chronobiology
and Human Ethology
ISSN 0172–780X

NEL VOL. 22 No. 5
Original Article

full text pdf (184kb)

2001; 22:332-336
pii: NEL220501A01

Increased Urinary 6-sulfatoxymelatonin Excretion in Women with Non-classical Steroid 21-hydroxylase Deficiency
Rafael Luboshitzky, Ghali Qupti, Avraham Ishay,
Zilla Shen-Orr & Paula Herer

melatonin, testosterone, adrenal hyperplasia, hyperandrogenism, androgens

Submitted: September 5, 2001
Accepted: September 12, 2001


OBJECTIVES: To determine melatonin production in hyperandrogenic women.

MATERIAL AND METHODS: Seventeen women with late onset adrenal hyperplasia due to 21-hydroxylase deficiency (LOCAH) and 15 control women were studied in early follicular phase of the menstrual cycle. Fasting serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), testosterone, dihydroepiandrosterone sulfate (DHEA-S), 17-hydroxyprogesterone (17-OHP) as well as the peak 17-OHP response to ACTH (250 µg IV) and 24h urinary 6-sulfatoxymelatonin (aMT6s) were determined in all participants.

RESULTS: All 17 hyperandrogenic women were carrying mutations of the CYP21 gene. Women with LOCAH had significantly higher serum testosterone, DHEA-S, 17-OHP and ACTH stimulated 17-OHP values compared with controls. Their aMT6s values (44.6±20.3 µg/24h) were significantly higher than the values in control women (31.5±20.3) (p<0.03). The urinary aMT6s values were positively correlated with testosterone (p<0.04), DHEA-S (p<0.02) and peak 17-OHP (p<0.04).

CONCLUSIONS: Women with LOCAH have increased melatonin production. There is a relationship between adrenal androgens and melatonin in these women.


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