Reproductive Medicine, Chronobiology
and Human Ethology, ISSN 0172780X
Vol.24 No.1/2, Feb-Apr 2003
function in diabetes mellitus
sonography for screening of gallbladder motility in diabetic
patients: Relation to autonomic and peripheral neuropathy
Ertugrul Kayacetin 1, Gurcan Kisakol 2, Ahmet
& Zehra Akpinar 3
Selcuk University Meram Medical Faculty, Department of Internal
medicine, Division of Gastroenterology, TURKEY.
2. Selcuk University Meram Medical Faculty, Department of
Internal medicine, Division of Endocrinology and Metabolism,
3. Selcuk University Meram Medical Faculty, Department of
November 7, 2002 Accepted: November 13, 2002
gallbladder, ultrasound, diabetes mellitus, autonomic
neuropathy, peripheral neuropathy
Diabetes mellitus is known as one of the factors causing the
cholesterol gallstone. Gallstone incidence is about 30% in
diabetic patients over 20 years of age. Pathophysiology is
still not clear. The aim of the present study was to investigate
gallbladder (GB) functions in diabetic patients and determine
its relationship with peripheral and autonomic neuropathy.
Study was performed between October 2001 and may 2002 in fifty-one
diabetic patients of similar age and weight. Diabetic patients
(n=51) were chosen randomly among diabetic patients, who were
being followed in Diabetes Out-patient clinics of Selcuk University,
Meram Medical Faculty. Twenty-eight control subjects were
chosen from healthy volunteers. We measured fasting and post-prandial
gallbladder volumes and ejection fractions by real-time ultrasonography.
The patients were divided into three groups; group A (n=18)
had no diabetic autonomic and peripheral neuropathy, group
B (n=13) had diabetic peripheral neuropathy, group C (n=13)
had diabetic autonomic neuropathy.
No significant difference in any biochemical parameters between
diabetic and control group could be found. Fasting gallbladder
volume was significantly higher in the diabetic group (5.31
± 0.28 cm3) compared to control group (4.19 ±
0.25 cm3, p<0.01). But there was no difference within diabetic
subgroups. Gallbladder ejection fraction was significantly
reduced in diabetic patients in groups B and C (29.7 ±
1.43%, 28.7 ± 1.28%) compared to group A (44.8 ±
2.4%; p<0.05, p<0.025 respectively).
Cholesterol crystal formation as a result of increased gallbladder
volume and decreased ejection fraction in diabetic patients
may result from hypotonicity and stasis and thus this may
lead to gallstones.
Copyright © Neuroendocrinology Letters 2003
Society of Integrated Sciences
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