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NEUROENDOCRINOLOGY LETTERS
including Psychoneuroimmunology, Neuropsychopharmacology,
Reproductive Medicine, Chronobiology
and Human Ethology, ISSN 0172–780X

NEL Vol.24 Nos.3/4, Jun-Aug 2003

ORIGINAL ARTICLE

Direct effects of cocaine-amphetamine-regulated transcript (CART) on pituitary hormone release in pituitary cell culture

2003; 24:224226
pii: NEL243403A12
PMID: 14523361

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Direct effects of cocaine-amphetamine-regulated transcript (CART) on pituitary hormone release in pituitary cell culture

Boguslawa Baranowska, Ewa Woliñska-Witort, Magdalena Chmielowska, Lidia Martyñska & Agnieszka Baranowska-Bik

Neuroendocrinology Dept. Medical Centre of Postgraduate Education Warsaw, POLAND.

Submitted: April 7, 2003
Accepted: May 1, 2003

Key words:
CART, pituitary hormones, cell culture

 

Abstract

OBJECTIVE: Cocaine- and amphetamine-regulated transcript (CART) is widely expressed in the rat brain, especially in the hypothalamic nuclei and in the anterior pituitary. The aim of this study was to evaluate the effects of CART on pituitary hormone release in pituitary cell culture.

MATERIAL AND METHODS: The pituitary hormone release from pituitary cell culture after CART administration was investigated. Concentrations of LH, FSH, PRL, TSH and GH were measured with RIA methods.

RESULTS: CART in all doses (1nMol, 10nMol, 100nMol) stimulated prolactin (PRL) release and inhibited TSH release. CART administration caused a dose dependent decrease in LH release. CART did not change GH release from cultured pituitary cells.

CONCLUSION: CART may affect directly pituitary hormones release in the cell culture.

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Copyright  Neuroendocrinology Letters 2003
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