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NEUROENDOCRINOLOGY LETTERS
including Psychoneuroimmunology, Neuropsychopharmacology,
Reproductive Medicine, Chronobiology
and Human Ethology, ISSN 0172–780X

NEL Vol.24 Nos.3/4, Jun-Aug 2003

REVIEW ARTICLE

Etiopathogenesis of Graves’ disease

2003; 24:161–166
pii: NEL243403R03
PMID: 14523350

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REVIEW ARTICLE

Etiopathogenesis of Graves’ disease

Michal Karasek & Andrzej Lewinski

1. Department of Endocrinology and Isotope Therapy, Medical University of Lodz – Polish Mother’s Memorial Hospital – Research Institute, Lodz, Poland.
2. Department of Electron Microscopy, Chair of Pathomorphology, Medical University of Lodz, Poland.

Submitted: December 18, 2002
Accepted: February 24, 200

Key words:
Graves’ disease, autoimmune diseases, hyperthyroidism, ophtalmopathy, dermopathy

 

Abstract

Graves’ disease is an autoimmune disorder, caused by thyroid-stimulating antibodies, which bind to and activate the thyrotropin receptor on thyroid cells, inducing the synthesis and release of thyroid hormones. It is a polygenic and multifactorial disease that develops as a result of complex interaction between genetic susceptibility and environmental and/or endogenous factors. Graves’ disease differs from other autoimmune diseases of the thyroid by specific clinical features, including hyperthyroidism, vascular goitre, ophthalmopathy and - less commonly – infiltrative dermopathy. This article discusses current theories, regarding the etiology and pathogenesis of Graves’ disease, including possible predisposing factors, autoimmune aspects of Graves’ disease, ophthalmopathy, and dermopathy.

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