Vol. 23 (2) 2002 Neuro endocrinology letters

The interaction of serum folate and estradiol levels in Alzheimer's disease.

OBJECTIVES: In vitro and in vivo animal studies suggest that sex steroids, such as estrogens and testosterone, could protect the brain. However, estrogen replacement therapy (ERT) for Alzheimer's disease (AD) in women has not been successful. We hypothesised that the lack of effect of ERT might be related to an interaction between estro.....