Vol. 24 (1-2) 2003 Neuro endocrinology letters

Responses of the HPA axis after chronic variable stress: effects of novel and familiar stressors.

OBJECTIVES: We examined the role that novelty plays in determining interactions between chronic and acute stress, when both the chronic and acute stressors emphasize emotional processing (i.e. stressful stimuli that do not present immediate threats to somatic homeostasis, and are processed primarily by limbic and forebrain circuits).