Luzindole but not 4-phenyl-2- propionamidotetralin (4P-PDOT) diminishes the inhibitory effect of melatonin on murine Colon 38 cancer growth in vitro.

Winczyk K, Fuss-Chmielewska J, Lawnicka H, Pawlikowski M, Karasek M.

Journal Article 2009; 30(5): 657-662 PubMed PMID: 20035258 Keywords: Animals, Cell Line, Tumor, Colonic Neoplasms:metabolism, Humans, Melatonin:metabolism, Mice, Receptors, Melatonin:antagonists & inhibitors, Tetrahydronaphthalenes:metabolism, Tryptamines:metabolism,.

OBJECTIVE: Our earlier studies have shown that MLT exerts the inhibitory effect on murine cancer via membrane and nuclear receptors. We have found that the antagonist of MT1 receptors does not diminish the antiproliferative effect of MLT on Colon 38 cells, and the contribution of MT2 receptors has been suggested to be responsible. There.....

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Vol. 30 (5) 2009 Neuro endocrinology letters

Luzindole but not 4-phenyl-2- propionamidotetralin (4P-PDOT) diminishes the inhibitory effect of melatonin on murine Colon 38 cancer growth in vitro.

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