Vol. 36 (2) 2015 Neuro endocrinology letters

Alternative splicing of placental lactogen (CSH2) in somatotroph pituitary adenomas.

OBJECTIVES: Somatotroph adenomas secrete supraphysiological amounts of GH, causing acromegaly. We have previously shown epithelial splicing regulator 1 (ESRP1) to play a role in epithelial mesenchymal transition (EMT) progression in these adenomas and account for poor treatment response. We evaluated if the mRNA levels of the GH/CSH ge.....