Vol. 39 (7) 2018 Neuro endocrinology letters

Tapentadol in an Experimental Animal Model of Acute Orofacial Pain.

OBJECTIVE: Tapentadol exhibits a synergistic dual effect effect (MOR / NRI) -agonist effect on noradrena-line reuptake inhibition (NRI). Tapentadol is effective on pain with neuropathic characteristics, therefore we decided to use it in an experimental model of acute orofacial pain. METHODS: The Orofacial Stimulation Test, d.....