Vol. 40 (2) 2019 Neuro endocrinology letters

Acute and chronic stress exert opposite effects on formation and contextualrelated fear conditioning in rats.

OBJECTIVE: Stress and fear conditioning are both involved in the development of affective disorders, but their interconnected relationship remains unclear. Here in this study we employed acute and chronic stress model to investigate their respective effect on fear conditioning and the CRFR1 signaling change in the limbic areas .....