Vol. 40 (6) 2019 Neuro endocrinology letters

Neuropeptide Y knockdown in the dorsomedial hypothalamus improved basal and obesity-induced decrease in bone mass density.

OBJECTIVE: Neuropeptide Y (NPY) has been shown to have a prominent role in the control of bone formation through the regulation of osteoblast activity. We aimed to investigate the role of hypothalamus-derived NPY in bone metabolism. METHODS: Accordingly, adeno-associated virus (AAV)-mediated RNA interference (.....