Vol. 25, Nos.1/2, Feb-Apr 2004

Guest Editorial by Editor-in-Chief
Guest Editorial
by Prof. Raphael Mechoulam
Guest Editorial
by Prof. Ester Fride

Review Article
Pharmacology of Cannabinoids
by Franjo Grotenhermen
Nova-Institut, Hrth, GERMANY
Key words: Cannabis; THC; cannabinoids; marijuana; pharmacodynamics; cannabinoid receptors; endocannabinoids; therapeutic use; side effects; interaction

The Endocannabinoid-CB Receptor System: Importance for development and in pediatric disease
Ester Fride
Departments of Behavioral Sciences and Molecular Biology, College of Judea and Samaria, ISRAEL
Key words: cannabinoids, endocannabinoids, CB1 receptors, Endocannabinoi-CB Receptor (ECBR) system, development, ontogeny, failure-to-thrive, implantation, teratology

Clinical Endocannabinoid Deficiency (CECD):
Can this Concept Explain Therapeutic Benefits of Cannabis in Migraine, Fibromyalgia, Irritable Bowel Syndrome and other Treatment-Resistant Conditions?

Ethan B. Russo, Missoula, MT 59802, USA
Running Headline: Clinical Endocannabinoid Deficiency (CECD)
Key words: cannabis; cannabinoids; medical marijuana; analgesia; migraine; headache; irritable bowel syndrome; fibromyalgia; causalgia; allodynia; THC; CBD

On the application of cannabis in paediatrics and epileptology
Rüdiger Lorenz, Bad Wildungen, GERMANY
Key words: Cannabinoids; children; epilepsy; ion channels; neurodegenerative disease; posthypoxic state; posttraumatic reaction; olfactory system

Cannabinoid agonists in the treatment of blepharospasm
A case report study by Benjamin Gauter, Roman Rukwied, Christoph Konrad
Department of Anaesthesiology, Clinical Faculty Mannheim, University of Heidelberg, GERMANY
Running title: Dronabinol therapy in blepharospasm
Key words: Cannabinoid; CB1 Receptor; Dronabinol; Botulinum Toxin; Blepharospasm, Dystonia

= = = = = = = = = = =

LAUDATIO: Prof. Antonin Dolezal 75 years

Original Article
Pregnant Women: Moir Contourgraph and its Semiautomatic and Automatic Evaluation

Karel Jelen, Sabina Kusova
Charles University in Prague, Faculty of Physical Education and Sport, Department of Anatomy and Biomechanics, Prague, CZECH REPUBLIC

Original Article

Immunocytes Modulate Ganglionic Nitric Oxide Release Which Later Affects Their Activity Level
Running title: ganglionic nitric oxide
Key words: nitric oxide, immunocytes, ganglia, ganglionic nitric oxide
George B. Stefano, Kirk Mantione, Dolisha Jones, Wei Zhu,
Federico Casares, and Patrick Cadet
Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY, USA

Original Article
Blood serum changes in patients with pain during bone fractures and acute pancreatitis

Karel Krikava 1, Karel Kalla 1, Anna Yamamotová 2, Richard Rokyta 2
Key words: acute pain, pancreatitis, fractures, serum biochemistry
1. Department of Surgery, Department of Clinical Biochemistry,
District Hospital Pelhrimov, CZECH REPUBLIC
2. Charles University, Third Faculty of Medicine, Department of Normal, Pathological and Clinical Physiology, Prague, CZECH REPUBLIC

Original Article
Qualitative and quantitative studies on the ultrastructure of ovine pinealocytes during postnatal development
Key words:
sheep; pineal gland; pinealocyte; ultrastructure; development; postnatal life
Bogdan Lewczuk 1, Barbara Przybylska-Gornowicz 1,
Henryk Brzostowski 2
1. Department of Histology and Embryology, Faculty of Veterinary Medicine;
2. Department of Sheep & Goad Breeding and Game Management,
Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, POLAND

Original Article
Effect of fasting during the month of Ramadan on serum levels of leutinizing hormone and testosterone in people living in the below sea level environment in the Jordan Valley
Running Title: Fasting and testosterone levels in humans
Key Words: Ramadan; Fasting; Leutinizing Hormone; Testosterone; Human; Below Sea Level
Fayig El-Migdadi, Ali Shotar, Zeyad El-Akawi, Ibrahim Banihani,
Rola Abudheese and Wajih Oweis
Departments of Biochemistry and Molecular Biology, Urology, and Forensic Medicine, School of Medicine and Department of Biology, School of Science Jordan University of Science and Technology Irbid, JORDAN

Original Article
Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray

Running title: Effect of Cortagen on gene expression
Key words: Gene Expression; Microarray; Brain Cortex; Peptides; Cortagen; Heart.
Sergey V. Anisimov,1, Vladimir Kh. Khavinson 1, Vladimir N. Anisimov 1,2
1. Saint-Petersburg Institute of Bioregulation and Gerontology, RAMS,
St.-Petersburg, RUSSIA.
2. N.N.Petrov Research Institute of Oncology, St.-Petersburg, RUSSIA

Original Article
Evaluation of Subretinal Fluid Absorption by Optical Coherence Tomography in Circumscribed Choroidal Hemangioma after Photodynamic Therapy with Verteporfin

Key words: circumscribed choroidal hemangioma, optical coherence tomography, photodynamic therapy, retinal thickness at fixation point, subretinal fluid absorption, verteporfin
Petr Soucek, Ilona Cihelková
The Eye Department, University Hospital of 3rd Medical Faculty, Prague, CZECH REPUBLIC

Original Article
Impaired somatostatin accumulation within the median eminence in mice with mosaic mutation

Running head: somatostatin accumulation in mosaic mice

Key words: mosaic mutant mice; copper deficiency; somatostatin; median eminence
Urszula Wojewodzka 1, Alina Gajewska 2, Barbara Gajkowska 1, Jozefa Styrna 3
& Kazimierz Kochman 2
1 Laboratory of the Cell Ultrastructure, Medical Research Center, Polish Academy of Sciences, Warsaw, POLAND
2 The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jablonna n. Warsaw, POLAND
3 Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Cracow, POLAND

Insulin-induced changes of proteolytic activity of the lysosomal enzymes
Key words: insulin; lysosomal enzymes; proteolytic activity; mice
Bozena Witek 1, Ewa Ochwanowska 1, Adam Kolataj 2, Teodora Król 1,
Danuta Baranowska 1 & Jan Rafay 3
1.Department of Genetics, Institute of Biology, Swietokrzyska Academy, POLAND
2. Institute of Genetics and Animal Breeding, Polish Academy of Sciences in Jastrzebiec near Warsaw, POLAND
3. Research Institute of Animal Production in Nitra, SLOVAK REPUBLIC

Original Article
Spontaneous ovarian adenocarcinoma in the domestic turkey breeder hen (Meleagris gallopavo):
Effects of photoperiod and melatonin"

Key words: cancer, avain, adenocarcinoma, melatonin, potoperiod, turkey, model, light
by C. B. Moore and T. D. Siopes
Department of Poultry Science, North Carolina State Universtiy, Raleigh,
North Carolina, USA

Original Article
Glucocorticoid-Dependency of Increased Adiposity in a Model of Hypothalamic Obesity

Running title: MSG and neuroendocrine-adipocyte interactions.
Key words: adrenalectomy; adrenal enucleation; ACTH; glucocorticoid; leptin; insulin.
Mario Perelló 1, Griselda Moreno 1, Rolf C. Gaillard 2 & Eduardo Spinedi 1
1. Neuroendocrine Unit, Multidisciplinary Institute on Cell Biology (CONICET-CICPBA), 1900 La Plata, ARGENTINA; and,
2. Division of Endocrinology, Diabetology & Metabolism, University Hospital (CHUV), CH 1011 Lausanne, SWITZERLAND.

Original Article
Light and electron microscopic examination of pineal gland in rats exposed to constant light and constant darkness
Key words: light; darkness; pineal gland; rat; light and electron microscopy
Ilter Kus 1, Mustafa Sarsilmaz 1, Oguz Aslan Ozen 2,
Asli Ozdem Turkoglu 1, Hidir Pekmez 1, Ahmet Songur 3
& Haluk Kelestimur 4
1. Department of Anatomy, Faculty of Medicine, Firat University, Elazig,
2. Department of Anatomy, Faculty of Medicine, Karaelmas University, Zonguldak,
3. Department of Anatomy, Faculty of Medicine, Kocatepe University, Afyon,
4. Department of Physiology, Faculty of Medicine, Firat University, Elazig, TURKEY.

Original Article
Melatonin effects on Schiff's base levels induced by iodide administration in rats

Key words: melatonin; Schiff's bases; iodide; lung; liver; brain
Dominika Swierczynska-Machura 1, Andrzej Lewinski 1,2,
Ewa Sewerynek 1,2
1 Department of Thyroidology;
2 Department of Endocrinology and Isotope Therapy; Institute of Endocrinology, Medical University of Ldz, POLAND

Impact of a switch from typical to atypical antipsychotic drugs on quality of life and gonadal hormones in male patients with schizophrenia
Running head: Antipsychotics, QoL and gonadal hormones
Key words: adverse events, extrapyramidal symptoms (EPS), hypothalamo-pituitary-gonadal (HPG) axis, prolactin, psychotic symptoms, quality of life (QoL)
Yasuhiro Kaneda, (1, 3), Ichiro Kawamura, (2), Akira Fujii, (2), Tetsuro Ohmori, (1)
(1) Department of Neuropsychiatry, The University of Tokushima School of Medicine, JAPAN
(2) Department of Neuropsychiatry, Fujii Hospital
(3) Department of Psychiatry, Vanderbilt University School of Medicine, Nashville. TN, USA

Original Article
Possible effects of melatonin on thymus gland after pinealectomy in rats

Key Words: melatonin; pinealectomy; thymus
by Hakan Öner (1), Ilter Kus (2), Jale Öner (1), Murat Ögetürk (2),
Enver Ozan (3), Ahmet Ayar (4)
(1) Department of Histology and Embryology, Faculty of Veterinary Medicine, Akdeniz University, Burdur;
(2) Department of Anatomy, Faculty of Medicine, Firat University, Elazig;
(3) Department of Histology and Embryology, Faculty of Medicine, Firat University, Elazig
(4) Department of Pharmacology, Faculty of Medicine, Firat University, Elazig,

Original Article
Increase of the IL-1b and IL-6 Levels in CSF in Patients with Vasospasm Following Aneurysmal SAH

Stanislaw Hendryk (1), Barbara Jarzab (1), Jadwiga Josko (2)
1. Dept of Neurosurgery and Neurotraumatology, Silesian Medical University, Bytom, POLAND.
2. Dept. of Nuclear Medicine and Endocrine Oncology, Center of Oncology-Maria-Sklodowska-Curie Memorial Institute, Gliwice. POLAND

Vol. 25, No.3, June 2004

Guest Editorial
What does freedom look like?
by Professor Jan Sokol, Faculty of Humanities, Charles University Prague, CZECH REPUBLIC

Review Articles

Environment- and gene-dependent human ontogenesis, sociogenesis and phylogenesis (eco-geno-onto-socio-phylogenesis)
Key words: functional teratogenesis; neuro-endocrine-immune-system; primary prevention; onto-socio-philogenesis
Günter Dörner
Institute of Experimental Endocrinology, Humboldt University Medical School (Charité), Berlin, GERMANY.

Periodic emergence of great poets in the history of Arabia & Persia, China and Japan
Key words: poetry, periodicity, synchronicity, Inanna
Emil Páleš - Sophia Foundation, Bratislava,
Miroslav Mikulecký Sen. - 1st medical Clinic, Comenius University, Bratislava,

Case Report
Precocious puberty associated with a Pineal cyst:
Is it disinhibition of the hypothalamic-pituitary axis?

Running Title: Precocius puberty and pineal cyst

Key words: precocious puberty; pineal cyst; neuroendocrinology; gonadal hormones
Rob D. Dickerman, Qualls E. Stevens, Jean-Alex. Steide, Steven J. Schneider
Dept. of Neurosurgery, North Shore University-Long Island Jewish Medical Center, New Hyde Park, NY, USA

Case Report
Vitamin B 12 plasma concentrations in Alzheimer disease
Hans Joerg Stuerenburg, Tomas Mueller-Thomsen & Axel Methner
Key words: Vitamin B 12, Alzheimer’s disease, dementia, rehabilitation, cognitive function, Minimental-Status examination
Neurological Department, Median-Klinik Bad Suelze, GERMANY,
2 Clinic for Psychiatry and Psychotherapy, University-Hospital Hamburg-Eppendorf, UKE, GERMANY,
3 Clinic for Neurology, University-Hospital Hamburg-Eppendorf, UKE, GERMANY

Original Articles:

The Effect of Vigabatrin, Lamotrigine and Gabapentin on the Fertility, Weights, Sex Hormones and Biochemical Profiles of Male Rats
Key words: Lamotrigine, Gabapentin, Vigabatrin, Fertility, Weight, Sex Hormones, Biochemical Profile
Daoud AS*, Bataineh H**, Otoom S***, Abdul-Zahra E*
Departments of Neuroscience*, Physiology** and Pharmacology***,
College of Medicine, Jordan University of Science and Technology, Irbid, JORDAN

Nitric Oxide Modulates the Physiological Control of Ciliary Activity in the Marine Mussel Mytilus edulis via Morphine: Novel mu opiate receptor splice variants
Running Headline: Ganglionic novel mu opiate receptors

Key words: opioid mechanisms; ciliary activity; morphine; dopamine, nitric oxide, mu3 opiate receptor subtype, presynaptic dopamine release, invertebrate
Patrick Cadet
Neuroscience Research Institute, SUNY College at Old Westbury, Old Westbury, New York, USA

Leptin gene expression in the hypothalamus and pituitary of pregnant pigs
Key words: leptin gene expression; hypothalamus; pituitary; gilt; early pregnancy

Nina Smolinska 1, Jadwiga Przala 1, Tadeusz Kaminski 1, Gabriela Siawrys 1, Alina Gajewska 2, Kazimierz Kochman 2 & Stanislaw Okrasa 1
1 Department of Animal Physiology, University of Warmia and Mazury in Olsztyn, Olsztyn-Kortowo, POLAND
2 The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jablonna n. Warsaw, POLAND

Serum testosterone and corticosterone levels in acute experimental autoimmune encephalomyelitis (EAE) in male Wistar rats
Running headline: Testosterone and corticosterone in EAE
Key words: stress, neuroendocrine interactions, testosterone, corticosterone, EAE
Daniela R. Maccio 1, Gaston Calfa 2, Marta Volosin 2 & German A. Roth 1

1. Departamento de Quimica Biologica - CIQUIBIC (CONICET) and
2. Departamento de Farmacologia. Facultad de Ciencias Quimicas. Universidade Nacional de Cordoba. Cordoba, ARGENTINA

The influence of chronic exposure to low frequency pulsating magnetic fields on concentrations of FSH, LH, prolactin, testosterone and estradiol in men with back pain
Marta Woldanska-Okonska 1, Michal Karasek 2,3 & Jan Czernicki 1,4
Key words: magnetic fields, magnetotherapy, magnetostimulation, FSH, LH, prolactin, testosterone, estradiol
1. Chair of Rehabilitation, Swietokrzyska Academy, Piotrkow Branch, POLAND
2. Department of Endocrinology and Isotope Therapy, Medical University of Lodz; Polish Mother’s Memorial Hospital – Research Institute, Lodz, POLAND
3. Department of Electron Microscopy, Chair of Pathomorphology, Medical University of Lodz, Lodz, POLAND
4. Department of Rehabilitation, Medical University of Lodz, Lodz, POLAND

Increased mitogen-induced lymphocyte proliferation in treatment resistant depression: A preliminary study
Key words: treatment resistant depression, blood lymphocytes, cytokines, immunity
Marta Kubera 1, Agnieszka Basta-Kaim 1, Andrzej Wróbel 2, Michael Maes 3, Dominika Dudek 2
1 Department of Endocirnology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Kraków, POLAND
2 Department and Clinic of Psychiatry, Medical College of Jagiellonian University, Kraków, POLAND
3 Department of Psychiatry, University of Maastricht, Maastricht, THE NETHERLANDS

The beneficial effect of amalgam replacement on health in patients with autoimmunity
Running Head: The beneficial effect of amalgam replacement on health

Key words: metal allergy; mercury allergy; autoimmunity, MELISA®; amalgam replacement; multiple sclerosis, systemic lupus erythematosus, autoimmune thyroiditis, atopic eczema
Jarmila Prochazkova, 1 Ivan Sterzl, 2 Hana Kucerova, 1 Jirina Bartova 1
& Vera DM Stejskal 3
1. The Institute of Dental Research 1st Medical Faculty Charles University and General, University Hospital, Prague, CZECH REPUBLIC
2. The Institute of Endocrinology, Prague, CZECH REPUBLIC

Hypothalamic nitric oxide synthase activity during sexual maturation in female rats. Effects of Estrogens.
Key words: nitric oxide, sexual maturation, Gn-RH, nitric oxide synthetase

Roxana Reynoso, Claudia Mohn, Berta Szwarcfarb, Osvaldo Ponzo,
Silvia Carbone, Pablo Scacchi* and Jaime A. Moguilevsky*
Departamento de Fisiologia, Facultad de medicina, Universidad de Buonos Aires and Universidad Favaloro*. Buenos Aires, ARGENTINA

Effect of bromocriptine on cell apoptosis and proliferation in GH3 cell culture
Key words: apoptosis, GH3 cells, bromocriptine
R. Wasko 1, M. Wolun-Cholewa 2, P. Bolko 1, M. Kotwicka 2
1 Department of Endocrinology and Metabolism and Internal Disease University of Medical Sciences, Poznan, POLAND
2 Department of Radiobiology and Cell Biology, University of Medical Sciences, Poznan, POLAND

Volume 25, No.4, August 2004

Review Articles:

The neurobiology of pleasure, reward processes, addiction and their health implications
Running title: Pleasure and addiction [PRESS RELEASE]
Key words: Pleasure, reward, addiction, motivation, placebo, dopamine, endorphins, health
Tobias Esch 1,3, George B. Stefano 2,3
1 Charité - University Medicine Berlin, Institute for General Practice and Family Medicine, Schumannstrasse 20/21, 10117 Berlin, GERMANY
2 Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York, 11568, USA
3Beijing Foreign Affairs University, Beijing Wellness Medical Center, South Stone Torii
Chang Ping, Beijing, CHINA

Direct measurement of free radicals in the brain cortex and the blood serum after nociceptive stimulation in rats
Runing title: Free radicals after nociceptive stimulation
Key words: EPR method, free radicals, pain, melatonin, rat
Richard Rokyta 1, Pavel Stopka 2, Václav Holecek 3, Karel Krikava 5, Ivana Pekárková 1,4
1 Charles University, 3rd Faculty of Medicine, Department of Normal, Pathological and Clinical Physiology, Prague,
2 Institute of Inorganic Chemistry, Czech Academy of Sciences, Prague,
3 Department of Clinical Biochemistry, Mulac´s Hospital, Plzen,
4 Department of Neurology, Hospital Benešov,
5 Department of Surgery, Hospital Pelhrimov,

Original Articles:

Isoproterenol-stimulated melatonin production by perifused rat pineal glands: Age- and time-related effects

Key words: melatonin; isoproterenol; pineal gland; rat; ageing
Lobna Naïri-Skandrani, Yasmina Djeridane, Henriette Charbuy & Yvan Touitou
Faculté de Médecine Pitié-Salpêtrière, Service de Biochimie Médicale et Biologie Moléculaire,
91, Boulevard de l'Hôpital, 75013, Paris, FRANCE

Treatment of giant paraclinoid aneurysms. Own experience
Key words: giant aneurysms; paraclinoid aneurysms; endovascular treatment; surgery
Pawel P. Kolasa 1, Zbigniew Kaurzel 2 & Andrzej Lewinski 3
1. Department of Neurosurgery,
2. Department of Radiology, Copernicus Province Hospital in Lodz,
3. Department of Endocrinology and Isotope Therapy, Medical University of Lodz, POLAND

Brain Differentiation and Preferred Partner Characteristics in Heterosexual and Homosexual Men and Women
Running head: Brain Differentiation
Key words: sexual orientation, brain differentiation, mate selection, partner preferences
Frank Muscarella, Vanessa A. Elias, Lenore T. Szuchman,
Department of Psychology, Barry University, Miami, FL, USA

Maternal and fetal hypothalamo-pituitary-adrenal axis: Different response depends upon the mode of parturition
Running headline: Maternal and fetal hypothalamo-pituitary-adrenal axis

Key words: Corticotropin-releasing factor; adrenocorticotropin; cortisol; DHEA; HPA axis
Tomasz Ochedalski 1, Agnieszka Lachowicz 2
1. First Department of Gynecology and Obstetrics,
2. Institute of Endocrinology, Department of Experimental Endocrinology and Hormone Research, Medical University of Lodz, POLAND

C-reaktive protein as a predictor of threatening preterm delivery
Key words: c-reacitve protein, oxytocinase, izooxytocinase, preterm delivery, vaginal culture
Alfred Reron, Hubert Huras, Maciej Szymik, Andrzej Jaworowski
Dept. of Septic Gynecology and Obstetrics, Collegium Medicum Jagiellonian University, Cracow, POLAND

A new ovarian denervation technique and it's effect on sexual cycle, conception rates and offspring numbers in rats
Running Title: The Effects of Ovarian Denervation in Rats

Key words: Ovarian Denervation, Sexual Cycle, Conception and Offspring Numbers, Rat
Ali Risvanli 1a, Huseyin Timurkan 1, M. Faik Ozveren 2, Cahit Kalkan 1
1 Deparment of Obstetric and Gynecology, Faculty of Veterinary, University of Firat, Elazig,
2 Deparment of Neurosurgery, Faculty of Medicine University of Firat, Elazig, TURKEY.

Cardiovascular risk factors in middle-aged women with subclinical hypothyroidism
Running Title: cardiovascular risks in hypothyroidism
Key words: Hypothyroidism, homocysteine, C-reactive protein, coronary heart disease, lipids
Rafael Luboshitzky 1,2 and Paula Herer 2
1 Endocrine Institute, Haemek Medical center, Afula (RL)
2 The Bruce Rappaport Faculty of Medicine (RL, PH), Technion, Institute of Technology, Haifa, ISRAEL

The hypothalamic-pituitary-thyroid axis in subjects with subclinical thyroid diseases: the impact of the negative feedback mechanism
Running title: HPT axis in subclinical thyroid disease.

Key words: HPT axis, negative feedback, subclinical hypothyroidism, subclinical hyperthyroidim
Paolo Falaschi, Antonio Martocchia, Antonella Proietti, Rosaria D'Urso, Serena Gargano, *Franco Culasso, Antonio Rocco
Chair of Internal Medicine and *Statistics, I and II Faculty of Medicine, University of Rome
"La Sapienza", ITALY.

Immune and Stress Responses in C57BL/6 and C3H/HeN Mouse Strains following photoperiod manipulation
Running title: Photoperiodic immune and stress responses in mice
Key words: day length, photoperiodism, seasonality, glycocorticoids, leukocytes
Michele L. Gatien, Andrew K. Hotchkiss, Gretchen N. Neigh,
Firdaus S. Dhabhar & Randy J. Nelson
Departments of Psychology, Neuroscience, Oral Biology, and Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH, USA

Bovine pars tuberalis secretions release growth hormone from rat pars distalis of pituitary gland
Running title: Pars tuberalis secretions release growth hormone from pars distalis

Key words: pars tuberalis, adenohypophysis, pars distalis, growth hormone
Martha Maria Lafarque, Marcelo Ezquer, Luis Inocencio Aguado & Liliana Beatriz Oliveros
Laboratorio de Biologia de la Reproduccion (LABIR), Departamento de Bioquimica y Ciencias Biologicas, Facultad de Quimica, Bioquimica y Farmacia, Universidad Ncional de San luis, San Luis, ARGENTINA

Case Study
Coexisting Acromegaly and Primary Empty Sella Syndrome
Running Title: Acromegaly and empty sella syndrome
Zeliha Hekimsoy 1, Nilgün Yünten 2, Seda Sivrioglu 3
1 Celal Bayar University Medical Faculty Department of Internal Medicine, Division of Endocrinology and Metabolism, Manisa, TURKEY
2 Ege University Medical Faculty, Department of Radiology, Izmir, TURKEY
3 Izmir Atatürk Training and Research Hospital, Department of Internal Medicine, Izmir, TURKEY

Zhenan Xue - ad multos transannos

Franz Halberg and Germaine Cornelissen, Co-Directors,
Robert. B. Sothern, Scientist, George S Katinas, Scientist, for the BIOCOS project
Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN 55455, USA.

Volume 25, No.5, October 2004

Dr. Katharina (Kittie) Dalton

Andrew & Christine Herxheimer

Reticuline Exposure to Invertebrate Ganglia Increases Endogenous Morphine Levels

Running title: Opiate alkaloid nitric oxide interaction
Key words: nitric oxide, opiate precursors, opiate metabolites, nervous tissue, invertebrates, mussels

Wei Zhu, Kirk J. Mantione and George B. Stefano
Neuroscience Research Institute, State University of New York College at Old Westbury

PRESS RELEASE: Morphine Synthesis in Animal Ganglia
[Ahead of Print, free full text]

Review Article:

Alzheimer Disease: Mercury as pathogenetic factor and apolipoprotein E as a moderator
Running head: Mercury and Alzheimer’s Disease

Key words: mercury, amalgam, Alzheimer’s disease, neurotoxicity, neurodegeneration, neurofibrillary tangles, Apolipoprotein E, metals.
Joachim Mutter, Johannes Naumann, Catharina Sadaghiani, Rainer Schneider*,
Harald Walach*
Institute for Environmental Medicine and Hospital Epidemiology, University Hospital Freiburg,
* Samueli Institute, European Office, Freiburg,

Original Articles:

Effects of long-term use Topiramate on fertility and growth parameter in adult Male Rats
Key words: Topiramate, fertility, growth, male rat
Sameer Otoom*, Hamed Batieneh**, Zuhair Hassan** and Azhar Daoud***
From the Departments of Pharmacology*, Physiology** and Neuroscience*** of Jordan University of Science and Technology
, Irbid, JORDAN

The change of regional brain metabolism (18FDG PET) in panic disorder during the treatment with cognitive behavioral therapy or antidepressants
Key words: panic disorder, neuroimaging, PET, brain metabolism, cognitive behavioral therapy, antidepressants
Ján Praško, Jirí Horácek, Richard Záleský, Miloslav Kopecek, Tomáš Novák, Beata Pašková, Lucie Škrdlantová, *Otakar Belohlávek, Cyril Höschl
Prague Psychiatric Centre, 3rd Faculty of Medicine Charles University,
Centre of Neuropsychiatric Studies,
*PET Centre, Hospital Na Homolce,

Intermittent hypoxia causes a suppressed pituitary growth hormone through somatostatin
Key words: Cysteamine; Growth hormone; Intermittent hypoxia; Rat; Somatostatin
Ning-Yi Xu 1, Xue-Qun Chen 1, Ji-Zeng Du 1*, Tong-Ying Wang,1and Cunming Duan 2
1 Division of Neurobiology and Physiology, College of Life Sciences, Zhejiang University (Yuquan Campus), Hangzhou 310027, CHINA
2 Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, Michigan 48109-1048, USA

Psychological, Neuroendocrine and Immune Measures in Non Spousal Carers of Disabled Elderly in Italy
Running title: Psycho-neuro-immune measures in carers

by Mauro Provinciali, Raffaella Moresi, Mario Muzzioli, Denis Tarabelli, Cristina Sirolla, Maria Gabriella Melchiorre, Maria Giovanna Tucci, Alberto Panerai, Paola Sacerdote, Massimo Mengani & Giovanni Lamura
• Immunology Center, I.N.R.C.A., Department of Gerontological and Geriatric Research, Ancona, ITALY;
• Centre of Health Economics, I.N.R.C.A., Department of Gerontological and
• Geriatric Research, Ancona, ITALY;
• Department of Pharmacology, University of Milan, Milan, ITALY.

Serum levels of growth factors HGF (hepatocyte groth factor), TGFb1 (transforming growth factor b1) and IGF-1 (insulin growth factor 1) in parathyroid tumors
Key words: parathyroid, tumor, HGF, TGFb1, IGF-I
Jaromír Astl 1,2, David Veselý 1, Petr Matucha 3, Jindrich Martínek 5, Tomáš Kucera 5,
Petr Laštuvka 1, Jan Betka 1,2, Ivan Šterzl 3,4
1 Department of Otorhinolaryngology, Head and Neck Surgery. The First Medical Faculty of the Charles University in Prague, University Hospital Motol,
2 ENT Department, Postgraduate Medical School. Prague, Czech Republic
3 Institute of Endocrinology. Prague,
4 Institute of Immunology and Microbiology. The First Medical Faculty of the Charles University in Prague, General University Hospital in Prague,
5 Institute of Histology and Embryology. The First Medical Faculty of the Charles University in Prague, General University Hospital in Prague, CZECH REPUBLIC

Investigation of the influence of training status on the relationship between the acute exercise and serum leptin levels in obese females
Oguz Ozcelik 1, Husnu Celik 2, Ahmet Ayar 1, Selami Serhatlioglu 3, Haluk Kelestimur 1
1 Department of Physiology, Faculty of Medicine, University of Firat, Elazig,
2 Department of Gynaecology and Obstetrics, University of Firat, Elazig,
3 Department of Radiology, Faculty of Medicine, University of Firat, Elazig, TURKEY

Salivary cortisol in panic: are males more vulnerable?
Running title: Salivary cortisol in panic

Key words: 35% CO2, challenge, gender differences, HPA axis, Panic Disorder, salivery cortisol, stress
Marlies A. van Duinen, Koen R.J. Schruers, Erika Jaegers, Michael Maes, Eric J.L. Griez
Maastricht University, Department of Psychiatry & Neuropsychology, and Vijverdal Academic Anziety Center, THE NETHERLANDS

The influence of antibiotic therapy on tocolysis in jeopardized advanced pregnancy
Monika Bobrzynska, Alfred Reron
Department of Septic Gynecology and Obstetrics, the Jagiellonian University, Cracow, POLAND

The hypothalamic-pituitary-thyroid axis and melatonin in humans: possible interactions in the control of body temperature
G. Mazzoccoli*, A. Giuliani*, S. Carughi*, A. De Cata*, F. Puzzolante*, M. La Viola*,
N. Urbano** , F. Perfetto † , R. Tarquini
* Department of Internal Medicine, Regional General Hospital "Casa Sollievo della Sofferenza", Cappuccini Av., S.Giovanni Rotondo (FG), ITALY,
** Department of Nuclear Medicine, Regional General Hospital "Casa Sollievo della Sofferenza", Cappuccini Av., S.Giovanni Rotondo (FG), ITALY,
† Center of Chronobiology, Medical University of Florence, Pieraccini Av., 50100 Florence (FI), ITALY

Volume 25, No.6, December 2004

The presence of heme-oxygenase and biliverdin reductase in human cranial ganglia indicates a role for carbon monoxide in neural transmission
Running title: Heme-oxygenese in human autonomic ganglia

Key words: biliverdin reductase; carbon monoxide; heme oxygenase; autonomic ganglia
Rolf Uddman 1 Janos Tajti 2 Frank Sundler 3 & Lars-Olaf Cardell 1
1. Department of Otorhinolaryngology, Malmö University Hospital, Malmö, SWEDEN
2. Department of Neurology, University of Szeged, Albert Szent-Györgyi Medical
and Pharmaceutical Center, Faculty of General Medicine, Szeged, HUNGARY
3. Department of Physiology and Neuroscience, Neuroendocrine Cell Biology,
Lund University, Lund, SWEDEN

Paradoxical firing of thalamic neurons under neuropathic pain state in rats
Running headline: Paradoxical firing of thalamic neurons

Key words: neuropathic pain; chaodynamic medhods; single unit activity; intralaminar nuclei; deafferentation; rat
Simon Vaculin 1, Miloslav Franek 1, Ladislav Andrey 2, Richard Rokyta 1
1 Department of Normal, Pathological and Clinical Physiology, Charles University, 3rd Faculty of Medicine, Prague, Czech Republic
2 Institute Of Computer Science, Czech Academy of Sciences, Prague, Czech Republic

Melatonin circadian rhythm in women with idiopathic hyperprolactinemia
Short title: Melatonin and hyperprolactinemia

Key words: melatonin; prolactin; hyperprolactinemia; circadian rhythm
Michal Karasek 1,2, Renata Stawerska 1, Maciej Hilczer 1, Krystyna Zylinska 3 &
Andrzej Lewinski 1
1. Department of Endocrinology an Isotope Therapy, Medical University of Lodz; Polish Mother’s Memorial Hospital – Research Institute, Lodz
2. Department of Electron Microscopy, Chair of Pathomorphology, Medical University of Lodz
3. Department of Experimental Endocrinology and Hormone Diagnostics, Institute of Endocrinology, Medical University of Lodz, Lodz, POLAND

The Naloxone test in Klinefelter Syndrome
Key words: Klinefelter syndrome, naloxone test, hypophyseal hormones, gonadal hormones, male infertility
Miroslaw Wielgos 1, Leszek Bablok 1, Stanislaw Fracki 1, Maciej Czaplicki 2,
Longin Marianowski 1

1 1st Department of Obstetrics and Gynecology, Medical University of Warsaw,
2 Department of Urology, Medical University of Warsaw, POLAND

Declining melatonin levels and older people. How old is old?
Key words: melatonin, ageing
Deborah Graham and Angus McLachlan
School of Psychology, James Cook University, Cairns, Queensland
Department of Psychology, University of Ballarat, Ballarat, Victoria, AUSTRALIA

Mechanism of ipamorelin-evoked insulin release from the pancreas of normal and diabetic rats
Running title: Ipamorelin and insulin secretion

Key words: insulin, diabetes mellitus, ipamorelin, radioimmunoassay, pancreas, adrenergic receptor antagonists, cholinergic receptor antagonist
Ernest Adeghate, Abdul Samad Ponery
Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, UNITED ARAB EMIRATES

Hyperprolactinemia after low dose of Amisulpride
Key words: amisulpride; prolactinemia; depression; side effects; safety
Miloslav Kopecek 1,2,3, Martin Bareš 1,2, Jirí Švarc 1, Colleen Dockery 1,3,
Jirí Horácek 1,2,3
1 Psychiatric Centre Prague, 2Charles University, 3rd School of Medicine in Prague,
3 Centre of Neuropsychiatric Studies in Prague, CZECH REPUBLIC

5-hydroxyindoleacetic acid and homovanillic acid concentrations in
cerebrospinal fluid in patients with Alzheimer's disease, depression and mild cognitive impairment

Key words: 5-hydroxyindoleacetic acid, 5-HIAA, homovanillic acid, HVA, cerebrospinal fluid, csf, alzheimer`s disease, mild cognitive impairment, depression, tau, beta-amyloid, abeta42, APOE, SSRI
Hans Joerg Stuerenburg*, Stefanie Ganzer**, Tomas Müller-Thomsen **
*Neurological Department, Median-Klinik Bad Suelze,
** Clinic for¨Psychiatry and Psychotherapy, University-Hospital Hamburg-Eppendorf, UKE,

Influence of the operative treatment of leiomyomas
on lipid profile

Key words: leiomyomas, hysterectomy, conservative myomectomy, lipids
Alfred Reron, Hubert Huras
Department of Septic Gynecology and Obstetrics, Collegium Medicum Jagiellonian University
Cracow, POLAND