October 19 , 2002
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Vol. 22 No. 6 Preview
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Neuroendocrinology Letters incl. Psychoneuroimmunology & Chronobiology

including Psychoneuroimmunology, Neuro
Reproductive Medicine, Chronobiology
and Human Ethology
ISSN 0172–780X


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THC-treatment in children suffering from
severe brain damage

(Ruediger Lorenz)

3 children suffering from severe brain damage (an 8 years old boy with NCL of Jansky Bielschovsky type, a 12 years old girl with a postpartal posthypoxic state and a 13 years old boy with athetosis, spasticity and imbecillity of unknown origin) I have treated with (-)- trans delta- 9-tetrahydrocannabinol, dosis was equivalent to about 0.07 mg/kg body weight per day divided in a morning and an evening application.

There was such a striking success in all 3 children, that I want to publish these observations before a detailed communication about the case history of the child suffering from NCL will follow in one of the next editions of NEL. The aim of this preliminary communication is to encourage all pediatricians and neurologists, who are worrying about children with the same or similar diseases, to try the application of THC in their patients.

The first patient`s mother a few days after the beginning of the treatment reported, that the boy had become more alert and cheerful; when she talked to him, he laughed and he looked more exactly in her direction. Diminished spasticity facilitated the application of the diapers.

The second patient`s mother reported about relaxation, softness, cheerfulness and openess for all and decrease of tonic seizures.

The third patient`s mother reported about more alertness, more cheerfulness and more looking of her child to her and a decrease of myoclonias (concerning intensity but not frequency).

In the first and in the third case it must be discussed, if discontinuation of other drugs partly has contributed to the described effects.

A more detailed discussion will follow in the announced case report.

Scheduled for publication in November
Vol. 23 No.5/6, 2002
Neuroendocrinology Letters www.nel.edu

More information available: publisher@nel.edu


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