children suffering from severe brain damage (an 8 years old
boy with NCL of Jansky Bielschovsky type, a 12 years old girl
with a postpartal posthypoxic state and a 13 years old boy
with athetosis, spasticity and imbecillity of unknown origin)
I have treated with (-)- trans delta- 9-tetrahydrocannabinol,
dosis was equivalent to about 0.07 mg/kg body weight per day
divided in a morning and an evening application.
was such a striking success in all 3 children, that I want
to publish these observations before a detailed communication
about the case history of the child suffering from NCL will
follow in one of the next editions of NEL. The aim of this
preliminary communication is to encourage all pediatricians
and neurologists, who are worrying about children with the
same or similar diseases, to try the application of THC in
first patient`s mother a few days after the beginning of the
treatment reported, that the boy had become more alert and
cheerful; when she talked to him, he laughed and he looked
more exactly in her direction. Diminished spasticity facilitated
the application of the diapers.
second patient`s mother reported about relaxation, softness,
cheerfulness and openess for all and decrease of tonic seizures.
third patient`s mother reported about more alertness, more
cheerfulness and more looking of her child to her and a decrease
of myoclonias (concerning intensity but not frequency).
the first and in the third case it must be discussed, if discontinuation
of other drugs partly has contributed to the described effects.
more detailed discussion will follow in the announced case
for publication in November
Vol. 23 No.5/6, 2002
Neuroendocrinology Letters www.nel.edu
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