Sulc M, Mrizova I, Cerna T, Frei E, Eckschlager T, Adam V, Kopeckova K, Stiborova M.
Journal Article 2016; 37(Suppl 1): 95-102 PubMed PMID: 28263536 Keywords: Antineoplastic Agents, Phytogenic:metabolism, Cytochrome P-450 CYP3A:metabolism, DNA Adducts:metabolism, Ellipticines:metabolism, Humans, Liposomes, Microsomes,. CitationOBJECTIVES: Ellipticine is an anticancer agent that functions through multiple mechanisms participating in cell cycle arrest and .....
Sulc M, Mrizova I, Cerna T, Frei E, Eckschlager T, Adam V, Kopeckova K, Stiborova M. Effectiveness of human cytochrome P450 3A4 present in liposomal and microsomal nanoparticles in formation of covalent DNA adducts by ellipticine. Neuro Endocrinol Lett. 2016 Dec; 37(Suppl 1): 95-102
Stiborova M, Manhartova Z, Hodek P, Adam V, Kizek R, Eckschlager T, Frei E.
Journal Article 2015; 36(Suppl 1): 22-28 PubMed PMID: 26757112 Keywords: Animals, Antineoplastic Agents:pharmacology, Cell Survival:drug effects, DNA Adducts:drug effects, Ellipticines:pharmacology, HL-60 Cells, Humans, In Vitro Techniques, Liver:drug effects, Micelles, Rats,. CitationOBJECTIVES: The improvements of cancer treatment are the major challenge in oncology research. Nanocarriers are one of the promising appro.....
Stiborova M, Manhartova Z, Hodek P, Adam V, Kizek R, Eckschlager T, Frei E. Cytotoxicity of and DNA adduct formation by ellipticine and its micellar form in human leukemia cells in vitro. Neuro Endocrinol Lett. 2015 Jan; 36(Suppl 1): 22-28
Hodek P, Fousova P, Brabencova E, Moserova M, Pavek P, Anzenbacherova E, Brotanek J, Hudecek J, Frei E, Stiborova M.
Journal Article 2014; 35(Suppl 2): 158-168 PubMed PMID: 25638381 Keywords: Animals, Benzo(a)pyrene:administration & dosage, Carcinogens:administration & dosage, DNA Adducts:administration & dosage, Flavonols:administration & dosage, Male, Rats, Rats, Wistar,. CitationOBJECTIVES: Flavanol dihydromyricetin (DHM) has been shown to counteract acute ethanol (EtOH) intoxication and reduce excessive E.....
Hodek P, Fousova P, Brabencova E, Moserova M, Pavek P, Anzenbacherova E, Brotanek J, Hudecek J, Frei E, Stiborova M. Effect of dihydromyricetin on benzo[a]pyrene activation in rats. Neuro Endocrinol Lett. 2014 Jan; 35(Suppl 2): 158-168
Stiborova M, Levova K, Barta F, Dracinska H, Sulc M, Hodek P, Frei E, Arlt V, Schmeiser H.
Journal Article 2014; 35(Suppl 2): 123-132 PubMed PMID: 25638376 Keywords: Animals, Aristolochic Acids:metabolism, Dicumarol:pharmacology, Enzyme Inhibitors:pharmacology, Humans, Quinone Reductases:metabolism, Rats,. CitationOBJECTIVES: Dicoumarol is known to act as an inhibitor of
NAD(P)H: quinone oxidoreductase (NQO1). T.....
Stiborova M, Levova K, Barta F, Dracinska H, Sulc M, Hodek P, Frei E, Arlt V, Schmeiser H. Dicoumarol inhibits rat NAD(P)H:quinone oxidoreductase in vitro and induces its expression in vivo. Neuro Endocrinol Lett. 2014 Jan; 35(Suppl 2): 123-132
Indra R, Moserova M, Sulc M, Frei E, Stiborova M.
Comparative Study 2013; 34(Suppl 2): 55-63 PubMed PMID: 24362093 Keywords: Animals, Benzo(a)pyrene:metabolism, Carcinogens:metabolism, Cytochrome P-450 CYP1A1:metabolism, Cytochromes b5:pharmacology, Humans, Inactivation, Metabolic, Male, Microsomes, Liver:drug effects, Oxidation-Reduction, Rats,. CitationOBJECTIVES: Cytochrome P450 (CYP) 1A1 is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (B.....
Indra R, Moserova M, Sulc M, Frei E, Stiborova M. Oxidation of carcinogenic benzo[a]pyrene by human and rat cytochrome P450 1A1 and its influencing by cytochrome b5 - a comparative study. Neuro Endocrinol Lett. 2013 Jan; 34(Suppl 2): 55-63
Stiborova M, Cerna V, Moserova M, Arlt V, Frei E.
Journal Article 2013; 34(Suppl 2): 43-54 PubMed PMID: 24362092 Keywords: Animals, Antineoplastic Agents:pharmacokinetics, Benzo(a)pyrene:pharmacology, Biotransformation:drug effects, Cytochrome P-450 CYP1A1:metabolism, Cytochrome P-450 CYP1A2:metabolism, Cytochrome P-450 Enzyme System:metabolism, Drug Evaluation, Preclinical, . CitationOBJECTIVES: The aim of this study was to investigate a role of cytochrome P450 (CYP) and peroxidase in ellipticine oxidative activation in.....
Stiborova M, Cerna V, Moserova M, Arlt V, Frei E. The effect of benzo[a]pyrene on metabolic activation of anticancer drug ellipticine in mice. Neuro Endocrinol Lett. 2013 Jan; 34(Suppl 2): 43-54