Articles by author - Juraj Harmatha

Different effect of two synthetic coumarin-stilbene hybrid compounds on phagocyte activity.

Drabikova K, Perecko T, Nosal R, Rackova L, Ambrozova G, Lojek A, Smidrkal J, Harmatha J, Jancinova V.

Journal Article 2010; 31(Suppl 2): 73-78 PubMed PMID: 21187835  Keywords:  Adult, Animals, Cell Line, Coumarins:pharmacology, Humans, Lipopolysaccharides:pharmacology, Macrophages:cytology, Male, Mice, Middle Aged, Models, Animal, Neutrophils:cytology, Nitric Oxide:metabolism, Phagocytosis:drug effects, Reactive Oxygen Species:m.    Citation

OBJECTIVE: Activated phagocytes, generating a variety of powerful inflammatory mediators, such as oxygen and nitrogen species, may partici.....

Read abstract  Full text PDF

Formation of reactive oxygen and nitrogen species in the presence of pinosylvin - an analogue of resveratrol.

Jancinova V, Nosal R, Lojek A, Ciz M, Ambrozova G, Mihalova D, Bauerova K, Harmatha J, Perecko T.

Journal Article 2010; 31(Suppl 2): 79-83 PubMed PMID: 21187828  Keywords:  Animals, Antioxidants:pharmacology, Antirheumatic Agents:therapeutic use, Arthritis, Experimental:drug therapy, Cell Line, Disease Models, Animal, Drug Therapy, Combination, Macrophages:cytology, Male, Methotrexate:therapeutic use, Neutrophils:drug effect.    Citation

OBJECTIVE: Formation of reactive oxygen species in neutrophils of rats with adjuvant arthritis and generation of nitric oxide in RAW 264.7.....

Read abstract  Full text PDF

In vivo effect of pinosylvin and pterostilbene in the animal model of adjuvant arthritis.

Macickova T, Drabikova K, Nosal R, Bauerova K, Mihalova D, Harmatha J, Pecivova J.

Journal Article 2010; 31(Suppl 2): 91-95 PubMed PMID: 21187826  Keywords:  Animals, Anti-Inflammatory Agents:pharmacology, Antioxidants:pharmacology, Arthritis, Experimental:drug therapy, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Therapy, Combination, Male, Oxidative Stress:drug effects, Peroxidase:metabolis.    Citation

OBJECTIVE: The aim of this study was to evaluate the effects of pinosylvin (PIN) and pterostilbene (PTE), natural substances from the stil.....

Read abstract  Full text PDF

Molecular targets of the natural antioxidant pterostilbene: effect on protein kinase C, caspase-3 and apoptosis in human neutrophils in vitro.

Perecko T, Drabikova K, Rackova L, Ciz M, Podborska M, Lojek A, Harmatha J, Smidrkal J, Nosal R, Jancinova V.

Journal Article 2010; 31(Suppl 2): 84-90 PubMed PMID: 21187824  Keywords:  Antioxidants:pharmacology, Apoptosis:drug effects, Caspase 3:metabolism, Cell Survival:drug effects, Computer Simulation, Dose-Response Relationship, Drug, Humans, In Vitro Techniques, Male, Neutrophils:cytology, Phosphorylation:drug effects, Protein Kina.    Citation

OBJECTIVE: Pterostilbene, a naturally occurring phenolic derivative, exhibits various pharmacological effects, e.g. anti-cancerous, antiox.....

Read abstract  Full text PDF

Suppression of oxidative burst in human neutrophils with the naturally occurring serotonin derivative isomer from Leuzea carthamoides.

Nosal R, Perecko T, Jancinova V, Drabikova K, Harmatha J, Svitekova K.

Journal Article 2010; 31(Suppl 2): 69-72 PubMed PMID: 21187819  Keywords:  Adult, Carcinogens:pharmacology, Dose-Response Relationship, Drug, Humans, Leuzea, Male, Middle Aged, Neutrophils:drug effects, Oxidative Stress:drug effects, Phosphorylation:drug effects, Plant Extracts:pharmacology, Protein Kinase C:metabolism, Reactive.    Citation

OBJECTIVE: Neutrophil leukocytes and macrophages represent professional phagocytic cells. When appropriately stimulated, they undergo dram.....

Read abstract  Full text PDF

Structure-efficiency relationship in derivatives of stilbene. Comparison of resveratrol, pinosylvin and pterostilbene.

Perecko T, Jancinova V, Drabikova K, Nosal R, Harmatha J.

Journal Article 2008; 29(5): 802-805 PubMed PMID: 18987580  Keywords:  Adenosine Triphosphate:metabolism, Antioxidants:pharmacology, Cell Survival:drug effects, Dose-Response Relationship, Drug, Humans, Luminescence, Neutrophils:drug effects, Reactive Oxygen Species:metabolism, Stilbenes:pharmacology, Structure-Activity Rela.    Citation

OBJECTIVES: Oxidative stress is related to a number of autoimmune diseases, e.g. rheumatoid arthritis, cancer, etc. The main source of pat.....

Read abstract  Full text PDF