Articles by author - Antonín Holý

Experimental approaches to studies on drug metabolism and drug interactions in man: interaction of acyclic nucleoside phosphonates with human liver cytochromes P450 and flavin-containing monooxygenase 3.

Matal J, Orság J, Nekvindová J, Anzenbacherová E, Veinlichová A, Anzenbacher P, Zídek Z, Holý A.

Journal Article 2006; 27(Suppl 2): 27-30 PubMed PMID: 17159773  Keywords:  Adenine:analogs & derivatives, Bacteria:ultrastructure, Cell Membrane:metabolism, Cytochrome P-450 Enzyme System:genetics, Drug Interactions, Humans, Liver:drug effects, Metabolic Detoxication, Phase I, Models, Biological, NADPH-Ferrihemoprotein Reductase.    Citation

OBJECTIVES: To determine a possible influence of acyclic nucleoside phosphonates on FMO3 and CYP activity at molecular level in vitro.

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