Articles by author - Jirí Horacek

Relationship of ketamine's antidepressant and psychotomimetic effects in unipolar depression.

Sos P, Klirova M, Novak T, Kohutova B, Horacek J, Palenicek T.

Journal Article 2013; 34(4): 287-293 PubMed PMID: 23803871  Keywords:  Adult, Antidepressive Agents:therapeutic use, Cross-Over Studies, Depressive Disorder, Major:drug therapy, Double-Blind Method, Female, Hallucinogens:therapeutic use, Humans, Infusions, Intravenous, Ketamine:therapeutic use, Male, Middle Aged, Receptors, .    Citation

OBJECTIVES: Ketamine and other NMDA (N-methyl-D-aspartate) antagonists produce fast-acting antidepressant-like effects, although the under.....

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The influence of clonidine on oral ketamine-midazolam premedication in intellectually disabled patients indicated for dental procedures: double-blind comparison of two sedation regimes.

Horacek J, Palenicek T, Malek J, Scigel V, Kurzova A, Hess L.

Clinical Trial 2012; 33(4): 380-384 PubMed PMID: 22936266  Keywords:  Adult, Anesthesia, Dental:methods, Clinical Protocols, Clonidine:administration & dosage, Dental Care for Disabled:methods, Disabled Persons, Dose-Response Relationship, Drug, Double-Blind Method, Drug Combinations, Drug Therapy, Combination:methods, Fema.    Citation

BACKGROUND: Dental procedures on intellectually disabled patients represent a clinical challenge. The oral administration of sedating drug.....

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Regional cerebellar metabolism (18FDG PET) predicts the clinical outcome of the short-term inpatient treatment of alcohol addiction.

Janu L, Rackova S, Horacek J.

Comparative Study 2012; 33(4): 419-424 PubMed PMID: 22936263  Keywords:  Adult, Alcohol Drinking:metabolism, Alcoholism:metabolism, Cerebellum:diagnostic imaging, Female, Fluorodeoxyglucose F18:metabolism, Humans, Male, Middle Aged, Positron-Emission Tomography:methods, Radiopharmaceuticals:metabolism, Time Factors, Treatment .    Citation

OBJECTIVES: The acute and maintenance treatment of alcohol addiction represents the clinical challenge. The aims of our study were to eval.....

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The effects of siRNA-mediated RGS4 gene silencing on the whole genome transcription profile: implications for schizophrenia.

Vrajová M, Peková S, Horácek J, Höschl C.

Journal Article 2011; 32(3): 246-252 PubMed PMID: 21712773  Keywords:  Brain-Derived Neurotrophic Factor:genetics, Cell Line, Cells, Cultured, Down-Regulation, Gene Expression Profiling, Gene Silencing, Genome, Human:genetics, Histones:genetics, Humans, Microarray Analysis, Nerve Tissue Proteins:genetics, Neurons:drug effect.    Citation

OBJECTIVE: The regulator of G-protein signaling (RGS) molecules represent a class of proteins that modulate the signaling activity of G-pr.....

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Combination of voxel based morphometry and diffusion tensor imaging in patients with Alzheimer's disease.

Ibrahim I, Horacek J, Bartos A, Hajek M, Ripova D, Brunovsky M, Tintera J.

Controlled Clinical Trial 2009; 30(1): 39-45 PubMed PMID: 19300399  Keywords:  Age Factors, Aged, Aged, 80 and over, Alzheimer Disease:diagnosis, Anisotropy, Corpus Callosum:diagnostic imaging, Diffusion Magnetic Resonance Imaging:methods, Echo-Planar Imaging:methods, Female, Humans, Male, Middle Aged, Organ Size, Psychological Test.    Citation

OBJECTIVE: The aim of the study was to assess structural changes in gray matter (GM) volume and fractional anisotropy (FA) in patients wit.....

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