Articles by author - Dagmar Kholova

Absorption kinetics of 5-aminosalicylic acid in rat: influence of indomethacin-induced gastrointestinal lesions and Escherichia Coli Nissle 1917 medication.

Kunes M, Kvetina J, Kholova D, Bures J, Tlaskalova-Hogenova H, Pavlik M.

Evaluation Studies 2011; 32(Suppl 1): 46-52 PubMed PMID: 22167206  Keywords:  Absorption, Animals, Anti-Inflammatory Agents, Non-Steroidal:adverse effects, Escherichia coli:physiology, Gastrointestinal Diseases:chemically induced, Gastrointestinal Tract:drug effects, Indomethacin:adverse effects, Kinetics, Male, Mesalamine:blood, O.    Citation

OBJECTIVES: The therapeutic effect of probiotics has been studied in many clinical and experimental studies but no data exist concerning t.....

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Caco-2 cells and Biopharmaceutics Classification System (BCS) for prediction of transepithelial transport of xenobiotics (model drug: caffeine).

Smetanova L, Stetinova V, Kholova D, Kvetina J, Smetana J, Svoboda Z.

Journal Article 2009; 30(Suppl 1): 101-105 PubMed PMID: 20027153  Keywords:  Biological Transport:drug effects, Caco-2 Cells, Caffeine:pharmacokinetics, Cell Culture Techniques, Cell Survival:drug effects, Diffusion, Humans, Hydrogen-Ion Concentration, Intestinal Absorption, Intestinal Mucosa:metabolism, Kinetics, Linear Models, M.    Citation

OBJECTIVES: The Caco-2 cell monolayer model is widely used as a standard screening tool for studying the mechanisms of cellular drug trans.....

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