Articles by author - Marta Kopeckova

Effectiveness of human cytochrome P450 3A4 present in liposomal and microsomal nanoparticles in formation of covalent DNA adducts by ellipticine.

Sulc M, Mrizova I, Cerna T, Frei E, Eckschlager T, Adam V, Kopeckova K, Stiborova M.

Journal Article 2016; 37(Suppl 1): 95-102 PubMed PMID: 28263536  Keywords:  Antineoplastic Agents, Phytogenic:metabolism, Cytochrome P-450 CYP3A:metabolism, DNA Adducts:metabolism, Ellipticines:metabolism, Humans, Liposomes, Microsomes,.    Citation

OBJECTIVES: Ellipticine is an anticancer agent that functions through multiple mechanisms participating in cell cycle arrest and .....

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The association between TaqI A polymorphism of ANKK1 (DRD2) gene and ADHD in the Czech boys aged between 6 and 13 years.

Paclt I, Drtilkova I, Kopeckova M, Theiner P, Serý O, Cermakova N.

Journal Article 2010; 31(1): 131-136 PubMed PMID: 20150882  Keywords:  Adolescent, Attention Deficit Disorder with Hyperactivity:epidemiology, Child, Czech Republic:epidemiology, Deoxyribonucleases, Type II Site-Specific:metabolism, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Male, Polymorphism, Rest.    Citation

OBJECTIVE: The purpose of this study was the correlation of the combined type of ADHD in children and Taq IA polymorphism DRD2 gene. We hy.....

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Dopamine beta hydroxylase (DBH) plasma activity in childhood mental disorders.

Paclt I, Koudelová J, Pacltova D, Kopeckova M.

Journal Article 2009; 30(5): 604-609 PubMed PMID: 20035263  Keywords:  Adolescent, Animals, Attention Deficit Disorder with Hyperactivity:blood, Biomarkers:metabolism, Child, Dopamine beta-Hydroxylase:blood, Female, Humans, Male, Mental Disorders:blood,.    Citation

BACKGROUND: Developmental study of dopaminergic and noradrenergic systems in child psychiatric disorders are rare. DBH activity is one of .....

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Some ADHD polymorphisms (in genes DAT1, DRD2, DRD3, DBH, 5-HTT) in case-control study of 100 subjects 6-10 age.

Kopecková M, Paclt I, Petrásek J, Pacltová D, Malíková M, Zagatová V.

Journal Article 2008; 29(2): 246-251 PubMed PMID: 18404133  Keywords:  Attention Deficit Disorder with Hyperactivity:genetics, Case-Control Studies, Child, DNA Mutational Analysis, Dopamine Plasma Membrane Transport Proteins:genetics, Dopamine beta-Hydroxylase:genetics, Female, Gene Frequency, Genetic Predisposition to Disea.    Citation

BACKGROUND: Pharmacological approach is the most effective way of treatment of ADHD and its early application prevents from the progress o.....

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Polymorphisms and low plasma activity of dopamine-beta-hydroxylase in ADHD children.

Kopecková M, Paclt I, Goetz P.

Journal Article 2006; 27(6): 748-754 PubMed PMID: 17187001  Keywords:  Adolescent, Attention Deficit Disorder with Hyperactivity:blood, Child, Dopamine beta-Hydroxylase:blood, Humans, Polymorphism, Genetic:genetics,.    Citation

: Attention-deficit Hyperactivity disorder (ADHD) is a multifactorial disorder clinically characterized by inattentiveness, impulsivity an.....

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Tyrosine kinase inhibitors vandetanib, lenvatinib and cabozantinib modulate oxidation of an anticancer agent ellipticine catalyzed by cytochromes P450 in vitro.

Kolarik M, Indra R, Adam V, Heger Z, Kopeckova K, Arlt V, Stiborova M.

Journal Article 2019; 39(7): 515-524 PubMed PMID: 30860683  Keywords:  Anilides:pharmacology, Animals, Cytochrome P-450 Enzyme Inhibitors:pharmacology, Ellipticines:pharmacokinetics, Humans, Microsomes, Liver:drug effects, Oxidation-Reduction:drug effects, Peroxidases:antagonists & inhibitors, Phenylurea Compounds:pharmacolo.    Citation

OBJECTIVES: Vandetanib¸ lenvatinib, and cabozantinib are tyrosine kinase inhibitors (TKIs) targeting VEGFR subtypes 1 and 2, EGFR and the.....

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