Stiborova M, Moserova M, Mrazova B, Kotrbova V, Frei E.
Journal Article 2010; 31(Suppl 2): 26-35 PubMed PMID: 21187821 Keywords: Animals, Antineoplastic Agents:metabolism, Biotransformation:drug effects, Cytochrome P-450 Enzyme System:physiology, DNA Adducts:drug effects, Ellipticines:metabolism, Kidney:metabolism, Liver:metabolism, Lung:metabolism, Male, Microsomes:drug effects, M. CitationOBJECTIVE: Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action. This anticancer agent should be consider.....
Stiborova M, Moserova M, Mrazova B, Kotrbova V, Frei E. Role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine: additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney. Neuro Endocrinol Lett. 2010 Jan; 31(Suppl 2): 26-35
Moserova M, Kotrbova V, Rupertova M, Naiman K, Hudecek J, Hodek P, Frei E, Stiborova M.
Journal Article 2008; 29(5): 728-732 PubMed PMID: 18987592 Keywords: Acetyl Coenzyme A:metabolism, Arylamine N-Acetyltransferase:metabolism, Arylsulfotransferase:metabolism, Autoradiography, Catalysis, DNA:chemistry, DNA Adducts:chemistry, Deoxyguanosine:chemistry, Ellipticines:chemistry, Hydrogen-Ion Concentration, Indica. CitationOBJECTIVES: Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of its action. Recently, we have found that 13-hyd.....
Moserova M, Kotrbova V, Rupertova M, Naiman K, Hudecek J, Hodek P, Frei E, Stiborova M. Isolation and partial characterization of the adduct formed by 13-hydroxyellipticine with deoxyguanosine in DNA. Neuro Endocrinol Lett. 2008 Oct; 29(5): 728-732
Kotrbová V, Aimová D, Brezinová A, Janouchová K, Poljaková J, Frei E, Stiborová M.
Evaluation Studies 2006; 27(Suppl 2): 18-22 PubMed PMID: 17159771 Keywords: Animals, Antineoplastic Agents:pharmacokinetics, Cytochrome P-450 Enzyme System:chemistry, DNA Adducts:metabolism, Ellipticines:pharmacokinetics, Metabolic Detoxication, Phase I, Microsomes, Liver:chemistry, Models, Biological, NADP:chemistry, NADPH-Ferri. CitationOBJECTIVES: Ellipticine is a potent antineoplastic agent exhibiting multiple action mechanisms. Recently, we found that after cytochrome P.....
Kotrbová V, Aimová D, Brezinová A, Janouchová K, Poljaková J, Frei E, Stiborová M. Cytochromes P450 reconstituted with NADPH: P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes. Neuro Endocrinol Lett. 2006 Dec; 27(Suppl 2): 18-22