Brain aging and testosterone-induced neuroprotection: studies on cultured sheep cortical neurons.

Journal Article 2013; 34(5): 395-401 PubMed PMID: 23922037 Keywords: Aging:metabolism, Animals, Cerebral Cortex:cytology, DNA Topoisomerases, Type II:genetics, DNA-Binding Proteins:genetics, Neurons:cytology, Neuroprotective Agents:pharmacology, Sheep, Testosterone:pharmacology, Tyrosine:analogs & derivatives, Up-Regulatio.

OBJECTIVE: This research reports the expression of topoisomerase βII in fetal sheep neuronal cells. The β isoform of DNA topoisomerase I.....

Expression and distribution of P450-aromatase in the ovine hypothalamus at different stages of fetal development.

Journal Article 2010; 31(5): 690-699 PubMed PMID: 21173749 Keywords: Age Factors, Animals, Aromatase:genetics, DNA, Complementary:metabolism, Female, Fetal Development:genetics, Fetus:metabolism, Gene Expression Regulation, Developmental, Gene Expression Regulation, Enzymologic, Gestational Age, Hypothalamus:metabolism, Im.

OBJECTIVES: An important step of sexual differentiation is the conversion of testosterone to estrogen by aromatase leading to masculinizat.....

Journal Article 2009; 30(4): 515-524 PubMed PMID: 20010498 Keywords: Androgens:pharmacology, Animals, Catalase:metabolism, Cell Division:drug effects, Cell Line, Transformed, Cell Survival:drug effects, Down-Regulation:drug effects, Drug Interactions, Glioma, Glucose:pharmacology, Mice, Microtubules:drug effects, Neuroblas.

OBJECTIVES: Diabetic complications can often affect the central nervous system since the chronic exposure to hyperglycemia can result in t.....

Journal Article 2006; 27(6): 807-812 PubMed PMID: 17187012 Keywords: Animals, Cell Differentiation:physiology, Cell Line, Tumor, Cell Shape, Mice, Neuroblastoma, Neurons:cytology, Neuroprotective Agents:administration & dosage, Oxidative Stress:physiology, Stem Cells:cytology, Testosterone:administration & dosage, Tyrosine.

OBJECTIVES: Using undifferentiated mouse neuroblastoma cells (C1300), we have previously observed that testosterone (T) exerts a neuroprot.....

Journal Article 2006; 27(4): 501-505 PubMed PMID: 16891994 Keywords: Animals, Cerebral Decortication, Corpus Callosum:cytology, Denervation, Frontal Lobe:cytology, Functional Laterality, Luteinizing Hormone:blood, Male, Neural Pathways, Occipital Lobe:cytology, Pituitary Gland, Anterior:metabolism, Rats, Rats, Wistar, Test.

OBJECTIVES: In addition to being regulated by the hypothalamo-hypophyseal system, testosterone (T) secretion is influenced by a number of .....