OBJECTIVES: Evidence has accumulated that an inflammatory, possibly autoimmune-mediated, process in the central nervous system (C.....
Melkersson K, Bensing S. Signs of impaired blood-brain barrier function and lower IgG synthesis within the central nervous system in patients with schizophrenia or related psychosis, compared to that in controls. Neuro Endocrinol Lett. 2018 Mar; 39(1): 33-42
OBJECTIVES: From the hypothesis that an impaired insulin and insulin-like growth factor cellular signalling in brain and body might result.....
Melkersson K. Sequencing of the insulin receptor (INSR) gene reveals association between gene variants in exon and intron 13 and schizoaffective disorder. Neuro Endocrinol Lett. 2018 Dec; 39(5): 371-379
OBJECTIVES: Type 1 diabetes mellitus (T1DM), resulting from an immune-associated destruction of insulin-secreting pancreatic β-c.....
Melkersson K, Wernroth M. Type 1 diabetes mellitus and the risk for schizophrenia or schizoaffective disorder: a Swedish nationwide register-based cohort study. Neuro Endocrinol Lett. 2019 Nov; 40(3): 125-134
OBJECTIVES: The aim of this study was to examine the effect of schizophrenia or schizoaffective disorder on the risk of developin.....
Melkersson K. Schizophrenia- or schizoaffective disorder diagnosis and the risk for subsequent type 1- or type 2 diabetes mellitus: a Swedish nationwide register-based cohort study. Neuro Endocrinol Lett. 2020 Dec; 41(5): 245-254
OBJECTIVES: Evidence has accumulated that an autoimmune-mediated process in the central nervous system may underlie the development of sch.....
Melkersson K, Bensing S. Increased antibody reactivity against insulin receptor-A and insulin like growth factor 1 receptor and their ligands in cerebrospinal fluid and serum of patients with schizophrenia or related psychosis. Neuro Endocrinol Lett. 2021 Sep; 42(5): 339-358
OBJECTIVES: Schizophrenia is a psychotic disorder with high heritability. There are also indications that impaired cellular signalling via.....
Melkersson K, Persson B. Association between single nucleotide polymorphisms in non-coding regions of the insulin (INS) gene and schizophrenia. Neuro Endocrinol Lett. 2022 Apr; 43(1): 1-8