Polish experiences with paternal lymphocyte immunization in women with recurrent miscarriages.

OBJECTIVE: This study aimed to evaluate the efficacy of PLI and results of subsequent pregnancy in women with RM showing alloimmune response.

MATERIALS AND METHODS: Immunological investigations were performed in patients with RM. Subsequently, PLI was administered to 241 patients at their request. Of these, 202 conceived between September 2005 and September 2012.

RESULTS: Of the 202 women, 169 pregnancies resulted in term delivery; the remaining 33 resulted in subsequent miscarriages (success rate = 83.7%). During seven-years observations of 202 tested individuals, 114 women were pregnant again for the second time and 92 pregnancies of them resulted in the next term delivery (success rate =80.7%).

CONCLUSIONS: Alloimmune background indicated that PLI might improve pregnancy outcome in patients suffering from RM. Long-term monitoring did not reveal any negative effects of PLI on the immunological system in the treated women or newborn babies.