Barta F, Levova K, Hodek P, Schmeiser H, Arlt V, Stiborova M.
Journal Article 2015; 36(Suppl 1): 13-21 PubMed PMID: 26757129 Keywords: Animals, Aristolochic Acids:metabolism, Arsenic:pharmacology, Balkan Nephropathy, Cadmium:pharmacology, Carcinogens:metabolism, Chromatography, High Pressure Liquid, Ions, Lead:pharmacology, Metals, Heavy:pharmacology, Microsomes, Liver:metabolism, Ochrat. CitationOBJECTIVES: Balkan endemic nephropathy (BEN) is a chronic progressive fibrosis associated with upper urothelial carcinoma (UUC). Aetiology.....
Barta F, Levova K, Hodek P, Schmeiser H, Arlt V, Stiborova M. The effects of heavy metal ions, phthalates and ochratoxin A on oxidation of carcinogenic aristolochic acid I causing Balkan endemic nephropathy. Neuro Endocrinol Lett. 2015 Jan; 36(Suppl 1): 13-21
Stiborova M, Levova K, Barta F, Dracinska H, Sulc M, Hodek P, Frei E, Arlt V, Schmeiser H.
Journal Article 2014; 35(Suppl 2): 123-132 PubMed PMID: 25638376 Keywords: Animals, Aristolochic Acids:metabolism, Dicumarol:pharmacology, Enzyme Inhibitors:pharmacology, Humans, Quinone Reductases:metabolism, Rats,. CitationOBJECTIVES: Dicoumarol is known to act as an inhibitor of
NAD(P)H: quinone oxidoreductase (NQO1). T.....
Stiborova M, Levova K, Barta F, Dracinska H, Sulc M, Hodek P, Frei E, Arlt V, Schmeiser H. Dicoumarol inhibits rat NAD(P)H:quinone oxidoreductase in vitro and induces its expression in vivo. Neuro Endocrinol Lett. 2014 Jan; 35(Suppl 2): 123-132
Stiborova M, Cechova T, Borek-Dohalska L, Moserova M, Frei E, Schmeiser H, Paca J, Arlt V.
Journal Article 2012; 33(Suppl 3): 8-15 PubMed PMID: 23353838 Keywords: Aerobiosis:physiology, Air Pollutants:pharmacokinetics, Anaerobiosis:physiology, Animals, Benz(a)Anthracenes:pharmacokinetics, Carcinogens:pharmacokinetics, Cytochrome P-450 Enzyme System:metabolism, Cytochrome-B(5) Reductase:genetics, DNA Adducts:metabol. CitationOBJECTIVES: 2-Nitrobenzanthrone (2-NBA) has recently been detected in ambient air particulate matter. Its isomer 3-nitrobenzanthrone (3-NB.....
Stiborova M, Cechova T, Borek-Dohalska L, Moserova M, Frei E, Schmeiser H, Paca J, Arlt V. Activation and detoxification metabolism of urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone by rat and mouse hepatic microsomes. Neuro Endocrinol Lett. 2012 Jan; 33(Suppl 3): 8-15
Stiborova M, Mares J, Levova K, Pavlickova J, Barta F, Hodek P, Frei E, Schmeiser H.
Journal Article 2011; 32(Suppl 1): 121-130 PubMed PMID: 22167220 Keywords: Animals, Aristolochic Acids:pharmacokinetics, Biotransformation, Carcinogens:pharmacokinetics, Cytochrome P-450 CYP1A1:genetics, Cytochrome P-450 CYP1A2, Cytochrome P-450 Enzyme System:genetics, Cytochromes:genetics, DNA Adducts:metabolism, Drug Evaluatio. CitationOBJECTIVE: The herbal drug aristolochic acid (AA) derived from Aristolochia species has been shown to be the cause of aristolochic acid ne.....
Stiborova M, Mares J, Levova K, Pavlickova J, Barta F, Hodek P, Frei E, Schmeiser H. Role of cytochromes P450 in metabolism of carcinogenic aristolochic acid I: evidence of their contribution to aristolochic acid I detoxication and activation in rat liver. Neuro Endocrinol Lett. 2011 Jan; 32(Suppl 1): 121-130
Martinek V, Kubickova B, Arlt V, Frei E, Schmeiser H, Hudecek J, Stiborova M.
Comparative Study 2011; 32(Suppl 1): 57-70 PubMed PMID: 22167209 Keywords: Acetyltransferases:chemistry, Animals, Aristolochic Acids:chemistry, Biotransformation:physiology, Catalytic Domain, Cells, Cultured, DNA Adducts:metabolism, Enzyme Activation, Humans, Lactams:metabolism, Models, Molecular, Molecular Conformation, NAD(P)H. CitationOBJECTIVES: Ingestion of aristolochic acid (AA) is associated with development of urothelial tumors linked with aristolochic acid nephropa.....
Martinek V, Kubickova B, Arlt V, Frei E, Schmeiser H, Hudecek J, Stiborova M. Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases. Neuro Endocrinol Lett. 2011 Jan; 32(Suppl 1): 57-70
Mizerovska J, Dracinska H, Arlt V, Schmeiser H, Frei E, Stiborova M.
Journal Article 2009; 30(Suppl 1): 52-59 PubMed PMID: 20027145 Keywords: Animals, Benz(a)Anthracenes:metabolism, Chromatography, High Pressure Liquid:methods, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System:metabolism, Humans, Inhibitory Concentration 50, Kinetics, Male, Microsomes, Liver:enzymology, Oxidati. CitationOBJECTIVES: 3-Aminobenzanthrone (3-ABA) is the main human metabolite of carcinogenic environmental pollutant 3-nitrobenzanthrone (3-NBA). .....
Mizerovska J, Dracinska H, Arlt V, Schmeiser H, Frei E, Stiborova M. Oxidation of 3-aminobenzanthrone, a human metabolite of carcinogenic environmental pollutant 3-nitrobenzanthrone, by cytochromes P450 - similarity between human and rat enzymes. Neuro Endocrinol Lett. 2009 Jan; 30(Suppl 1): 52-59