Articles by author - Ondrej Zendulka

Effects of combined treatment with cognitive enhancer memantine and antidepressant fluoxetine on CYP2D2 metabolic activity in rats.

Zendulka O, Jurica J, Zahradnikova L, Sabova M, Sulcova A.

Journal Article 2011; 32(5): 727-732 PubMed PMID: 22167136  Keywords:  Animals, Antidepressive Agents:pharmacokinetics, Aryl Hydrocarbon Hydroxylases:metabolism, Brain:drug effects, Cognition:drug effects, Dextromethorphan:blood, Dopamine Agents:pharmacokinetics, Drug Interactions, Drug Therapy, Combination, Enzyme Activatio.    Citation

OBJECTIVES: The drug-drug interactions can result in alterations of the therapeutical responses. The present study was designed to investi.....

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Intersexual differences in inhibitory influence of trans-resveratrol on activity of cytochrome P450 2D2 in rats.

Zendulka O, Totusek J, Sulcova A.

Journal Article 2009; 30(Suppl 1): 88-91 PubMed PMID: 20027150  Keywords:  Animals, Aryl Hydrocarbon Hydroxylases:antagonists & inhibitors, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System:metabolism, Dextromethorphan:chemistry, Dextrorphan:chemistry, Enzyme Inhibitors:pharmacology, Female, Liver:drug effects, .    Citation

OBJECTIVES: Differences in the metabolism between males and females have been seen over time. Hormonal regulation of cytochrome P450 activ.....

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