OGTT-Evoked Neuromedin U Response and Gastrointestinal Pattern of Regional mRNA Expression in MSG-Induced Obesity in Rats.
BACKGROUND: Neuromedin U (NMU) is a neuropeptide broadly expressed in the gastrointestinal (GI) tract and central nervous system (CNS), implicated in energy balance and glucose homeostasis. Recent studies have suggested that NMU may act as a "decretin" hormone by inhibiting glucose-stimulated insulin secretion (GSIS); however, in vivo f.....