Vol. 23 (2) 2002 Neuro endocrinology letters

Morphine down regulates human vascular tissue estrogen receptor expression determined by real-time RT-PCR.

UNLABELLED: Human vascular endothelial cells express the estrogen receptor-beta (ER-beta), which can be modulated by the opiate alkaloid morphine.

OBJECTIVES: To determine if morphine is capable of down regulating the ER-beta receptor in a similar fashion as the mu opiate receptor since they are both coupled to c.....