Neuroimmunotherapy of untreatable metastatic solid tumors with subcutaneous low-dose interleukin-2, melatonin and naltrexone: modulation of interleukin-2-induced antitumor immunity by blocking the opioid system.

Lissoni P, Malugani F, Malysheva O, Kozlov V, Laudon M, Conti A, Maestroni G.

Clinical Trial 2002; 23(4): 341-344 PubMed PMID: 12195238 Keywords: Adjuvants, Immunologic:administration & dosage, Aged, Antineoplastic Agents:administration & dosage, Carcinoma, Neuroendocrine:drug therapy, Carcinoma, Renal Cell:drug therapy, Digestive System Neoplasms:drug therapy, Female, Humans, Injections, Subcutane.

OBJECTIVES: The preliminary applications of the psychoneuroimmunological knowledges to the treatment of human diseases have confirmed the possibility to amplify IL-2-dependent anticancer immunity by the pineal hormone melatonin (MLT) or by opioid antagonist, such as naltrexone (NTX), which act by activating TH1 lymphocytes or suppressin.....

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Vol. 23 (4) 2002 Neuro endocrinology letters

Neuroimmunotherapy of untreatable metastatic solid tumors with subcutaneous low-dose interleukin-2, melatonin and naltrexone: modulation of interleukin-2-induced antitumor immunity by blocking the opioid system.

Treatment of macular degeneration (a controlled case).

Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa.

The problem of goitre with particular consideration of goitre resulting from iodine deficiency (II): management of non-toxic nodular goitre and of thyroid nodules.

The problem of goitre with particular consideration of goitre resulting from iodine deficiency (I): classification, diagnostics and treatment.

Effect of functional pinealectomy on hippocampal lipid peroxidation, antioxidant enzymes and N-methyl-D-aspartate receptor subunits 2A and 2B in young and old rats.

Inhibition of 2-nitropropane-induced cellular proliferation, DNA synthesis and histopathological changes by melatonin.

Presence of isoquinoline alkaloids in molluscan ganglia.

The effects of interleukin-6, leukemia inhibitory factor and interferon-gamma on STAT DNA binding and c-fos mRNA levels in cortical astrocytes and C6 glioma cells.

Dehydroepiandrosterone regulation of prolactin gene expression in the anterior pituitary does not depend on galanin induction.

C-fos gene expression induced in cells in specific hypothalamic structures by noxious mechanical stimulation and its [correction of it's] modification by exposure of the skin to extremely high frequency irradiation.

Cyproterone acetate-ethinyl estradiol treatment alters urinary 6-sulfatoxymelatonin excretion in hyperandrogenic women.

Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: a pilot study.

Preferred partner characteristics in homosexual men in relation to speculated patterns of brain differentiation.

Effects of putative male pheromones on female ratings of male attractiveness: influence of oral contraceptives and the menstrual cycle.

Human body odour, genetic variability, and sexual orientation: a reply to D. Oliva.

Mating types in yeast, vomeronasal organ in rodents, homosexuality in humans: does a guiding thread exist?

Aspirin-sensitive asthma due to diffuse neuroendocrine system pathology.

Multifaceted purinergic regulation of stimulus-secretion coupling in the neurohypophysis.

Editorial.