Vol. 23 (Suppl 1) 2002 Neuro endocrinology letters

Differential regulation by melatonin of cell growth and androgen receptor binding to the androgen response element in prostate cancer cells.

OBJECTIVES: The pineal hormone melatonin inhibits the growth of benign human prostate epithelial cells and the androgen-dependent prostate cancer LNCaP cells. In the androgen-nonresponsive prostate carcinoma PC3 cells melatonin inhibits cell growth only at high but not low cell density. We have recently found that melatonin causes nucle.....